摘要
目的探讨联合应用生长抑素联合灯盏花素注射液治疗急性胰腺炎(AP)的疗效。方法选择2008年1月至2012年12月该院收治符合标准的AP患者120例,分成单一治疗组(A组)、联合治疗组(B组)和综合治疗对照组(C组),各40例。C组:重症监护、改善重要脏器微循环、营养支持和常规使用抗菌药物等治疗;A组:在C组治疗基础上应用醋酸奥曲肽注射液首剂0.1 mg静脉注射、醋酸奥曲肽注射液0.3 mg加入生理盐水(NS)500 mL中静脉滴注,维持24 h,共7 d;B组:在A组治疗基础上,同时应用灯盏花素注射液20 mg加NS 250 mL静脉滴注,每天1次,共7 d,比较各组治疗前后急性生理与慢性健康(APACHEⅡ)积分、血小板计数(Plt)、血小板平均体积(MPV)、中转手术率、病死率、住院时间及住院费用。结果治疗后A、B组患者APACHEⅡ积分、Plt和MPV较C组均改善,差异有统计学意义(P<0.05),而B组改善程度更为明显,与A组比较,差异有统计学意义(P<0.05);治疗后B组中转手术率、病死率、住院时间及住院费用均明显低于A组及C组,差异有统计学意义(P<0.05)。结论 Plt和MPV变化能反映AP病情的变化,联合应用生长抑素和灯盏花素注射液治疗AP具有良好疗效。
Objective To investigate the effect of somatostatin combined with breviscapine injection in treating acute pancreatifis（AP）. Methods A total of 120 patients,who met the criterion and were received in the hospital from January 2008 to December 2012, were selected and divided into single treatment group （group A）, combined treatment group （group B ） and com- prehensive treatment group （group C ）, 40 eases in each group. The group C was with intensie care,improvement of mieroeireua- tion to important organs, nutrition support, routine application of antibacterial drugs and so on;the group A was additionally in- jected intravenously of first O. 1 mg octreotide acetate injection and 500 mL normal saline （NS） after injecting 0.3 mg octreotide acetate injection for 24 hours on the basis of group C, totally 7 days;the group B was with 20 mg breviseapine injection with 250 niL NS for intravenous injection on the basis of group C and group A ,once daily ,totally 7 days. The acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ ） scores, blood platelet count （Ph）, mean platelet volume （MPV）, conversive rate of surgery, death rate, hospital stay and hospitalization expense in all groups before and after treatment were compared. Results Compared with the group C, the APACHE Ⅱscore, Plt and MPV of the patients in group A and group B improved obviously, and the differ enee had statistical significance （P〈0.05）, moreover,the group B improved more obviously than group A. After treatment, the conver sive rate of the surgery, death rate,hospital stays and hospitalization costs in group B were significantly lower than those in both group A and group C with statistically significant difference （P〈0.05）. Conclusion Changes of Plt and MPV can reflect changes of AP, and combination of somatostatin and breviscapine injection has good effect in treating patients with AP.
出处
《现代医药卫生》
2014年第3期357-358,共2页
Journal of Modern Medicine & Health
