摘要
目的：观察烧伤患者血清NT-proBNP变化情况，探讨其临床价值。方法选择2011年4月-2013年4月本科收治的烧伤患者共64例。按1970年烧伤严重程度分级标准，将所有患者分为A、B、C、D四组，连续测定烧伤后8 h、24 h、48 h、72 h、5 d、7 d的血清NT-proBNP水平，并进行统计分析。结果烧伤后8h、24 h和48 h各组血清NT-proBNP水平均在正常值范围，此后B、C、D组NT-proBNP水平迅速升高超过正常值，各组间和各时间点间比较差异有统计学意义（P〈0.05），峰值在72 h或5 d；烧伤严重程度分级越高，血清NT-proBNP水平升高幅度越大，严重烧伤患者在伤后7 d血清NT-proBNP水平亦未恢复正常。结论烧伤患者血清NT-proBNP水平升高具有滞后性，连续监测NT-proBNP对病情评估和预后判断有良好临床价值。
Objective To observe the change of NT-proBNP in serum and study the clinical value. Methods 64 cases of burn patients treated in our department from April 2011 to Apirl 2013 were selected and divided into A, B, C, D group by standard of burn severity in 1970. The concentration levels of NT-proBNP in serum were measured at the time 8 hours, 24 hours, 48 hours, 72 hours, 5 days and 7 days after burn occurred and analyzed. Results The concentration levels of NT-proBNP in serum were within the normal range at the time 8 hours, 24 hours and 48 hours after burn. Then the levels in B, C and D groups were increased rapidly above the normal value, and it had significant differences among different groups and time points （P〈0.05）, and the peak appeared in 72 hours or 5 days after burn. The higher classification of burn severity was, the more conspicuous it was increasing range of NT-proBNP in serum. It would not be normal 7 days after burn that concentration levels of NT-proBNP in serum in patients with severe burns. Conclusion It is hysteresis of the concentration levels of NT-proBNP in serum in patients with burns. It has good clinical value to disease assessed and prognosis determined by monitoring NT-proBNP continuously.
出处
《中国实用医药》
2014年第1期19-20,共2页
China Practical Medicine
