摘要
目的:通过观察非霍奇金淋巴瘤(NHL)患者调节性T淋巴细胞(Treg)及白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α在疾病不同阶段的水平,探索这些免疫因素在NHL预后中的作用。方法:将87例NHL患者按临床预后分为无事件存活组64例、复发组14例、难治组9例,另设健康对照20例,动态观察Treg细胞及IL-6、TNF-α在疾病不同阶段的水平。结果:初治时NHL患者外周血Treg细胞比例、IL-6、TNF-α较对照者显著升高(P<0.05);其中难治组和复发组在起病时的Treg及IL-6水平较无事件存活组更高(P<0.05),而TNF-α水平差异无统计学意义。停止治疗时所有NHL患者外周血Treg、IL-6、TNF-α的水平与对照者比较差异无统计学意义;停止治疗后3个月及6个月时Treg、CD4+T淋巴细胞比例有升高趋势,复发组IL-6、TNF-α较无事件存活组升高,但差异无统计学意义。结论:Treg细胞可能在NHL发病及疾病进展中起促进作用,监测IL-6及TNF-α的表达水平对早期判断难治患者和预测复发可能有重要的临床意义。
Objective：To investigate the levels of regulatory T cells（Treg）and concentrations of interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）in peripheral blood of patients with non-Hodgkin＇s lymphoma（NHL） and to explore their roles in the pathogenesis and prognosis.Method：Eighty-seven patients with NHL were divided into three groups：events-free survival group（n=64）,relapse group（n=14）and refractory group（n=9）,healthy control group（n=20）was set up as well.The levels of Treg cells and concentrations of IL-6and TNF-αin periph- eral blood of patients were analyzed during different periods.Result：The levels of Treg cells and concentrations of IL-6were significantly higher in NHL patients,especially in relapse and refractory groups（P〈0.05）,while there was no difference in TNF-α.At the end of chemotherapy,the levels of Treg cells and concentrations of IL-6and TNF-αhad no difference with healthy control group.More Treg cells and higher concentrations of IL-6and TNF-α were seen in relapse group than those in event-free group at the time of 3months or 6months off treatment（P 〉0.05）.Conclusion：Treg cells may play a key role in the pathogenesis and development of NHL.IL-6and TNF-α may be useful factors for predicting the relapse and refractory of NHL.
出处
《临床血液学杂志》
CAS
2014年第1期32-34,39,共4页
Journal of Clinical Hematology
基金
2011深圳市科技计划项目(No:201102028)
