摘要
目的探讨血清超敏C反应蛋白(hs-CRP)、和肽素及血清淀粉样蛋白A(SAA)水平对评估慢性阻塞性肺疾病(COPD)急性加重期患者近期转归的价值。方法选取COPD急性加重期患者101例,于患者入院时、疾病缓解期和出院后6个月分别检测血清hs-CRP、和肽素及SAA水平,并对血清hs-CRP、和肽素及SAA水平与慢性阻塞性肺疾病全球倡仪(GOLD)分级、患者一般资料及治疗效果的关系进行分析。结果急性加重期、缓解期和出院后6个月患者血清hs-CRP、和肽素及SAA水平比较差异有统计学意义(P<0.01);急性加重期患者血清hs-CRP、和肽素及SAA水平显著高于缓解期和出院后6个月,差异有统计学意义(P<0.05);出院后6个月患者血清SAA水平显著低于缓解期,差异有统计学意义(P<0.05);缓解期患者血清hs-CRP及和肽素水平与出院后6个月时比较差异无统计学意义(P>0.05)。不同GOLD分级患者血清hs-CRP水平比较差异有统计学意义(P<0.01),GOLD分级Ⅲ级患者血清hs-CRP水平显著高于Ⅰ级和Ⅱ级患者,差异有统计学意义(P<0.05),GOLD分级Ⅳ级患者血清hs-CRP水平显著高于Ⅱ级患者,差异有统计学意义(P<0.05)。不同GOLD分级患者血清和肽素及SAA水平比较差异无统计学意义(P>0.05)。血清hs-CRP水平与COPD患者的病程和白细胞计数呈正相关(P<0.05),血清和肽素水平与白细胞计数呈正相关(P<0.05),血清SAA水平与病程呈正相关(P<0.05)。入院时患者血清hs-CRP水平与患者的住院时间、住重症监护病房(ICU)人数、住院死亡人数、6个月内死亡和恶化人数、6个月内恶化时间均无明显的相关性(P>0.05)。血清和肽素水平与患者的住院时间、住ICU人数、6个月内死亡和恶化人数、6个月内恶化时间有明显的相关性(P<0.05,P<0.01)。血清SAA水平与住ICU人数、6个月内死亡人数有明显的相关性(P<0.05,P<0.01)。结论血清和肽素水平与COPD患者的住院时间、病情严重程度、疾病
Objective To study the value of serum high-sensitivity C-reactive protein （hs-CRP）, copeptin and serum amyloid A（SAA） levels for evaluating short-term outcome of patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods A total of 101 patients with acute exacerbation of COPD were selected. Serum hs-CRP,copepetin and SAA levels were detected respectively at the time of admission, disease-free period and 6 months after discharge, then the correlation of hs-CRP, eopeptin and SAA levels with GOLD class, general data and therapeutic efficacy was analyzed. Results There were significant differences in serum hs-CRP, copeptin and SAA levels among the acute exacerbation, disease-free period and 6 months after discharge（ P 〈 0.01 ）. The levels of serum hs-CRP, copeptin and SAA in acute exacerbation stage were significantly higher than those in disease-free period and 6 months after discharge （ P 〈 0.05 ）. The serum SAA level in 6 months after discharge was significantly lower than that in disease-free period （ P 〈 0.05 ）. There was no significant difference in serum hs-CRP and copeptin levels between disease-free period and 6 months after discharge （P 〉 0.05 ）. There was significant difference in serum hs-CRP level among the patients of different GOLD class （P 〈 0.01 ）. The serum hs-CRP level in patients of GOLD class m was significantly higher than that in patients of GOLD class I and 11 （P 〈 0.05 ） , and the serum hsCRP level in patients of GOLD class 1V was significantly higher than that in patients of GOLD class II （P 〈 0.05 ）. There was no significant difference in serum copeptin and SAA levels among the patients of different GOLD class（ P 〉 0.05 ）. The serum hs-CRP level was positively related to the course of disease and lencocyte count（ P 〈 0.05 ）, the serum copeptin level was positively related to lencocyte count （P 〈 0.05 ）, the serum SAA level was positively related to the course of disease （ P 〈 0.05 ）.
出处
《新乡医学院学报》
CAS
2014年第1期38-41,共4页
Journal of Xinxiang Medical University
关键词
慢性阻塞性肺疾病
超敏C反应蛋白
和肽素
血清淀粉样蛋白A
chronic obstructive pulmonary disease
high-sensitivity C-reactive protein
copeptin
serum amyloid A
