摘要
目的通过完全随机对照设计方案,观察红花注射液对脓毒性休克患者病情评估及临床预后的影响,研究其治疗脓毒性休克的有效性。方法脓毒性休克患者,随机分为两组,在常规使用早期目标导向治疗(EGDT)的基础上,研究组使用红花注射液抗休克,记录各组APACHEⅡ评分,比较组间差异,抗休克治疗前后差异,比较红花注射液对脓毒性休克患者病情评估及临床预后的影响。结果两组患者抗休克治疗前后总体比较、死亡亚组比较、对照组存活亚组比较,APACHEⅡ评分无统计学差异(P>0.05),两组患者28d病死率无统计学意义(P>0.05),研究组存活亚组使用红花注射液抗休克治疗前后比较,APACHEⅡ评分有统计学差异(P<0.05)。结论红花注射液在促进脓毒性休克患者APACHEⅡ评分降低,改善病情,提高生存率方面有一定临床意义。
Objective To observe the effects of safflower injection on the condition evaluation and clinical prognosis in the septic shock patients through completely randomized design. Method Septic shock patients, randomly divided into two groups on the basis of routine use the early goal-directed therapy （EGDT）. The study group used safflower injection against shock. Recording APACHE II scores of the two groups, the differences between the two groups and the differences before and after treat- ment of shock were compared. Results APACHE I1 scores had no significance before and after treatment in the two group. There was no significance of 28 days mortality between the two groups （P 〉 0. 05） , While there was significance in APACHE II scores before and after treatment in survival subgroup of the study group （P 〈 0. 05 ）. Conclusion Safflower injection should de- crease APACHE II scores in patients with septic shock, and improve the condition of patients and the survival rate.
出处
《四川医学》
CAS
2013年第12期1777-1779,共3页
Sichuan Medical Journal
基金
四川省科学技术厅2011年重点科技项目课题(编号:川科计﹝2011SZZ001﹞)
