摘要
目的观察术前高剂量阿托伐他汀负荷对急性冠脉综合征(ACS)患者PCI术后肾功能的影响。方法择期PCI介入治疗的118例ACS患者随机分为两组:高剂量负荷组术前12h予阿托伐他汀40mg口服,术前2h再给予40mg口服,术后继续20mg/d治疗;对照组术前不予阿托伐他汀,仅术后予阿托伐他汀20mg/d治疗。测定PCI前后患者血肌酐(Scr)、尿素氮(BUN)、肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、血清C反应蛋白(CRP)水平,观察并比较两组患者造影剂肾病(CIN)的发生率,以及心肌损伤标志物、炎症指标变化。结果高剂量负荷组患者CIN发生率为1.69%,明显低于对照组11.86%(P<0.05)。PCI术后两组患者cTnI、CK-MB和CRP水平均较术前有明显增高(P<0.05),但高剂量负荷组明显低于对照组(P<0.05)。结论 PCI术前高剂量阿托伐他汀负荷可减少ACS患者术后CIN发生率,该保护效应可能与其减轻围手术期心肌损伤和炎症反应有关。
Objective To explore the effect of preoperative high-dose atorvastatin load on renal function in patients with acute coronary syndrome（ACS） undergoing percutaneous coronary intervention （PCI）. Methods 108 ACS patients undergoing PCI were randomly divided into two groups, the high-dose load group and the control group. The perioperative Scr and BUN, cT- hi, CK-MB, CRP and incidence of contrast-induced nephropathy （CIN） were compared between the two groups. Results 1.69% of patients in the high-dose load group developed CIN versus 11.86% of those in the control group, cTnI, CK-MB, CRP elevated in both groups postoperatively, however, those in the high-dose load group were significantly lower than those in the con- trol group. Conclusion Preoperative high-dose atorvastatin load might prevent CIN in patients with ACS undergoing PCI. An- ti-inflammatory effects might be involved in this renal protection2
出处
《四川医学》
CAS
2013年第11期1690-1691,共2页
Sichuan Medical Journal
关键词
急性冠脉综合征
冠脉介入治疗
他汀强化
肾功能
acute coronary syndrome
percutaneous coronary intervention
enhanced perioperative statin therapy
renal function
