摘要
目的 探讨骨科植入物相关耐甲氧西林金黄色葡萄球菌（MRSA）感染患者临床合理应用抗菌药物的方法。方法 在2006～2010年对在宽城满族自治县医院治疗的骨科器械植入MRSA感染患者进行回顾性研究。结果 在中位随访时间391 d内有18例患者（35%）MRSA治疗失败。利用Cox比例危险率模型,发现手术保留人工植入物[风险比（HR）,4.9;95%CI,1.3～18.2;P=0.017]及单一药物抗菌治疗（HR,4.4;95%CI,1.2～16.3;P=0.025）为清创术后治疗失败的独立预测因素。结论 患有骨科器械植入MRSA的患者需要保留植入物时,应考虑联合使用抗菌药物。
Objective To investigate drug resistance and antimicrobial combination against methicillin-resistant Staph- ylacoccu aureus （MRSA） isolated from rational orthopedic device-related infection （ODRI） patients, and to select rational antimicrobial agents for MRSA infection. Methods A retrospective cohort study of patients with MRSA ODRI who were treated in our hospital between 2000 and 2008 was done. Results During a median follow-up of 391 d （4 - 2 922 d）, 18 （35%） patients experienced treatment failure involving MRSA persistence or recurrence. With a cox proportional hazards model, implant retention hazard ratio （HR）, 4.9; 95% confidence interval （CI）, 1.3 - 18.2; P = 0.017 and single-agent antimicro- bial therapy （HR： 4.4; 95% CI： 1.2 - 16.3; P = 0.025） were independent predictors of treatment failure after debridement. Conclusion Combination of antimicrobials should be considered for patients with MRSA ODRI, especially when implant removal is not feasible.
出处
《中南药学》
CAS
2013年第12期938-941,共4页
Central South Pharmacy
