摘要
为证实维拉帕米用于急性心衰诱导的可行性 ,对杂种犬静点盐酸维拉帕米诱导心衰 ,并记录各项指标。结果 :主动脉收缩压下降 2 9% ,主动脉舒张压下降 2 7% ,左心室压力最大上升速率 ( +dp/dt)下降 4 7.5% ,左心室压力最大衰减速率 ( -dp/dt)下降 57.5% ,心率下降 30 .6% ,心排出量下降 34 .2 % ,心内膜下活力指数下降 1 3.8% ,冠状动脉血流量下降 4 0 .3% ;而肺毛细血管楔压 (简称肺毛压 )上升 70 .5%。在维持量静点中 ,上述指标能维持在较稳定的水平。提示维拉帕米静脉注射可产生满意的心衰效果 。
To determine the role of verapamile in induction of acute heart failure, Inj. Verapamile and ten dogs were used in the experiment. The experimental procedure is as follows: ① general anesthesia and insertion of the monitoring lines, ② induction of acute heart failure with Verapamile, ③ the collection of data, ④ statisticse. The result shows that: after a satisfied induction of heart failure, there is a significant decrease in aortic systolic pressure (-29%), aortic diastolic pressure (-18.5%), +d p /d t (-47.5%), -d p /d t (57.5%), HR ( -30.6% ), Cardiac output (-34.2%), endocardial viability ratios (-13.8%), and coronary flow ( -40.3% ). However there is a significant increase in pulmonary capillary wedge pressure (70.5%). In conclusion, in the acute experiment, the administration of Verapamile is an effective mothed in animal model of heart failure.
出处
《首都医科大学学报》
CAS
2000年第4期312-314,共3页
Journal of Capital Medical University
