摘要
目的探讨常规疗法加用多索茶碱治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的疗效和安全性。方法 80例AECOPD的患者随机分为治疗组和对照组各40例,治疗组在常规治疗基础上加多索茶碱0.3 ivgtt,每日1次,连用7 d;对照组在常规治疗基础上,加用氨茶碱0.25 ivgtt,每日1次,连用7 d。结果治疗组总有效率为90.0%,与对照组总有效率(72.5%)相比,差异有显著性(P<0.05)。治疗组肺功能、动脉血压氧分压、动脉血氧饱和度的改善明显优于对照组。治疗组不良反应发生率为10%,对照组不良反应发生率为27.5%,治疗组不良反应发生率明显低于对照组。结论多索茶碱可有效改善AECOPD患者的症状,其不良反应少,是一种安全有效的治疗AECOPD的药物。
【Objective】To explore the efficacy and safety of Doxofylline in treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. 【Methods】In 80 cases of AECOPD patients were randomly di- vided into treatment group and control group with 40 cases in each group. The treatment group was treated with Doxofylline 0.3 ivgtt, qd for 7 days and conventional therapy. The control groups were treated with theophylline 0.25 ivgtt, qd for 7 days and conventional therapy. 【Results】Compared the total efficiency of treatment group（90.0%） with the total efficiency of control group（72.5%）, the difference was significant（P 0.05）. The treatment group of pulmonary function, arterial blood pressure, oxygen partial pressure of arterial oxygen saturation improved signifi- cantly better than the control group. The incidence rate of adverse reactions in treatment group was 10%, the inci- dence rate of adverse reactions in control group was 27.5%, incidence rate of adverse reaction in treatment group was significantly lower than the control group. 【Conclusions】Doxofylline can effectively improve the symptoms of the patients with AECOPD, fewer adverse reactions, is a safe and effective treatment for AECOPD drugs.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第33期86-88,共3页
China Journal of Modern Medicine
关键词
慢性阻塞性肺疾病
多索茶碱
疗效
chronic obstructive pulmonary disease
Doxofylline
efficacy
