摘要
目的：评价蒙药清肺润泽丸联合化疗治疗初治和复治继发型肺结核临床疗效，探讨该药对抗结核药物增效、增敏，促进空洞闭合、痰茵转阴、改善症状等作用。方法：采用随机、单盲、平行对照的研究方法，将初治和复治继发型肺结核患者分为试验组和对照组，试验组初治采用前两个月强化期用乙胺丁醇、异烟肼、利福平及吡嗪酰胺，每日1次；后四个月用异烟肼及利福平，每日1次（2HRZE／4HR）加清肺润泽丸（10∥日）和复治采用前两个月强化期用链霉素、乙胺丁醇、异烟肼、利福平及吡嗪酰胺，每日1次；第三个月用乙胺丁醇、异烟肼、利福平及吡嗪酰胺，每日1次；后五个月巩固期用异烟肼、利福平及链霉素，每日1次（2SHRZE／1HRZE／5HRE）加清肺润泽丸（10g／日），对照组采用上述标准化疗方案。肺部病灶吸收率，痰茵转阴率，病症显效率为观察指标。结果：初治患者治疗第1个月、第2个月试验组肺部病灶吸收的患者比例高于对照组，第3～6个月肺部病灶明显吸收的患者比例试验组优于对照组，试验组治疗后肺部病灶吸收率明显降低，与对照组比较有统计学意义（P〈0．05）；复治患者治疗后第4—8个月试验组肺部病灶明显吸收与吸收的患者比例高于对照组，差异有统计学意义（P〈0．05）。试验组治疗第3个月痰茵转阴率达到100％高于对照组，有显著性差异（P〈0．05）。试验组改善病症较快，在治疗后第2个月各种病症明显好转，痊愈率试验组优于对照组，有显著性差异（P〈0．05）。结论：清肺润泽丸联合化疗治疗初治和复治继发型肺结核临床疗效显著，对化疗药具有增效、增敏作用。
Objective：To evaluate the Mongolian medicine Qingfeirunze pill combined with chemotherapy in the treatment of the primary treated and retreatment secondary pulmonary tuberculosis,to investigate the function of this medicine for anti tuberculosis clrugs of synergism,sensitiza- tion, the promotion of cavity closure ,the sputum negative conversion rate and improve symptoms. Methods： the primary treated and retreat- merit of patients with pulmonary tuberculosis were divided into the test group and the control group by randomized,single blind area and paral- lel control, the test group of the primary treated was given 2HRZE/4HR and Qingfeirunze pill （ 10g a day） ,retreatment was given 2SHRZE/ 1HRZE/5HRE and Qingfeirunze pill （ 10g a day） and control group using the standard chemotherapy. The absorption rate of lung lesions.the sputum negative conversion rate and effective rate of symptoms were observed. Results： The absorption rate of lung lesions of the primary treated patients, one and second months after treatment, the proportion of patients in the test group were higher than the control group;from third to six months after treatment the obvious absorption of Lung lesions of test group was better than control group, the difference between the two groups were statistically significant （ P 〈0. 05 ） ; from fourth to eight months after treatment the proportion of the obvious absorption of lung lesions and absorption in retreatment patients in test group were higher than in control group, the difference was statistically significant（ P 〈0. 05 ）. The test group for third months, the sputum negative conversion rate is 100%, higher than the control group, there were significant differences （P 〈 0.05 ）. test group improved symptoms rapidly, significantly improved in the second months after treatment, cure rate of test group was better than control group, there were significant differences （ P 〈 0.05 ）. Conclusion： combination of Mongolian medicine Qingfeirunze pill with chemotherapy i
出处
《中药药理与临床》
CAS
CSCD
北大核心
2013年第6期155-159,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
内蒙古自治区蒙医药标准化建设项目2010BZH12B04
关键词
清肺润泽丸
继发型肺结核
临床观察
Qingfeirunze pill（清肺润泽丸）
secondary pulmonary tuberculosis
clinical observation
