摘要
目的探讨妊娠晚期B族链球菌(GBS)带菌者应用敏感抗生素预防性治疗的疗效及治疗时机。方法以98例妊娠晚期GBS检测阳性者作为研究对象,其中接受治疗的68例为研究组,未接受治疗的30例为对照组。研究组中,临产或胎膜早破时给予敏感抗生素的36例为研究组1,发现GBS阳性即选用敏感抗生素口服治疗7天,临产或胎膜早破时再次给予抗生素的32例为研究组2。分别比较研究组与对照组之间、研究组1与研究组2之间的胎膜早破、早产、宫内感染、新生儿感染、产褥感染情况。结果研究组与对照组的胎膜早破及早产的发生率比较,差异无统计学意义(P>0.05),宫内感染、新生儿感染、产褥感染的发生率差异有统计学意义(P<0.05),研究组均低于对照组。研究组1与研究组2的胎膜早破、早产、宫内感染、新生儿感染、产褥感染的发生率差异均无统计学意义(P>0.05)。结论妊娠晚期GBS带菌者应用敏感抗生素预防性治疗可明显改善母婴结局,预防性治疗的时机选择以临产或胎膜早破时用药为宜。
Objective To investigate the curative effect and treatment time about application of Sensitive antibiotics prophylactic treatment on the GBS positive gravidas in late pregnancy. Methods Research of 98 cases of GBS positive gravidas in late pregnancy. The treatment for 68 cases of the study group, and the untreated 30 cases is contrasting group. Among the study group, there are 36 case ap- plying sensitive antibiotics prophylactic when parturiency or premature rupture of membranes. We name these as study group 1. Study group 2 is composed by GBS Positive gravidas who are given sensitive antibiotics treatment for 7 days and then give antibiotic during partu- riency or premature rupture of membranes. Results After comparing the different situation of premature rupture of membranes, preterm delivery, intrauterine infection, neonatal infection and puerperal infection among the groups, it shows that only the difference of incidence on intrauterine infection,neonatal infection and puerperal infection is statistically significant between the study group and the contrasting group（ P 〈 0.05）. Both of the study group are lower than contrasting group; the difference of the incidence of premature rupture of mem- branes, preterm delivery,intrauterine infection,neonatal infection and puerperal infection had no statistical significance between the study group 1 and study group 2 （P 〉 0.05）. Conclusion It is effective to apply sensitive antibiotics prophylactic treatment on the GBS posi- tive gravidas in late pregnancy and the best treatment period is parturiency or premature rupture of membranes.
出处
《医学研究杂志》
2014年第1期111-113,共3页
Journal of Medical Research
