摘要
目的在蛋清体模中比较SonoVue和介孔二氧化硅纳米微球包裹的氟碳化合物增强高强度聚焦超声(HIFU)治疗效果差异,筛选适合HIFU治疗的增效剂。方法将SonoVue和包裹液态全氟戊烷的介孔二氧化硅纳米微球(MSNC-PFP)各0.3ml分别均匀混合到100ml的蛋清体模中,制成SonoVue组和MSNC-PFP组2个实验组,空白组不含增效剂。在B超引导下采用声功率160W的HIFU定点辐照10s,记录辐照区域即刻灰度变化,对比分析辐照后灰度变化区域、损伤体积、损伤形态以及能效因子(EEF)。结果辐照区回声增强范围与损伤大小一致,回声增强范围SMSNC-PFP组>SSonoVue组≥S空白组;损伤体积VMSNC-PFP组>VSonoVue组≥V空白组;EEFMSNC-PFP组<EEFSonoVue组≤EEF空白组。MSNC-PFP组损伤形态皆为圆锥体,偏向换能器方向的损伤边缘类似棉花状,边缘局部有空隙;而SonoVue组和空白组的损伤形状皆为水滴状,边界清晰且无空隙。结论 MSNC-PFP能较SonoVue更有效地提高HIFU治疗效率。
Objective To compare the difference between SonoVue and perfluoropentane droplets-encapsulated mesoporous silica nanocapsules for improving high-intensity focused ultrasound（HIFU） treatment effect using egg white phantoms, and to choose suitable HIFU synergist. Methods About 0.3 ml SonoVue （SonoVue group） and perfluoropentane drops-encapsulated mesoporous silica nanocapsules （MSNC-PFP group） were premixed into 100 ml phantoms separately, and control group was without synergist. HIFU dot irradiating was performed in the egg white phantoms for 10 s with power of 160 W. Gray changing of irradiated area immediately after irradiation was real-timely monitored by ultrasound. Gray area changing immediately after HIFU ablation, as well as the volume, laws of damage＇s shape and energy efficiency factor （EEF） were analyzed. Results The damaged volume was similar to changing area of gray scale. Echo enhancements were found SMSNOPFp 〉SsonoVue ≥Scontrol , damaged volumes were VMSNCPFP 〉VsonoVue≥Vcontrol , while EEFs were EEFMsNCPFp EEFsonoVue≤EEFcontrol. The damaged area of MSNC-PFP group was cone shaped, with boundary towards to transducer similar to cotton and of gaps, while the other 2 groups were quasi water-drop shaped. All the damage boundary was clear and voidless, except of MSNC-PFP group. Conclusion MSNC-PFP may be more efficient than SonoVue in HIFU therapy.
出处
《中国介入影像与治疗学》
CSCD
2014年第2期103-106,共4页
Chinese Journal of Interventional Imaging and Therapy
基金
国家重点基础研究发展计划(973计划)项目(2011CB707900、2012CB722402)
国家自然科学基金(81127901、11274404、11304382)
重庆市自然科学基金(CSTC2010BB5368)
重庆市科委重点实验室专项经费
关键词
高强度聚焦超声消融术
造影剂
增效剂
全氟戊烷
High-intensity focused ultrasound ablation
Contrast mendia
Synergists
Perfluorohexane
