摘要
子宫内膜异位症(endometriosis,EMs)为炎症性疾病和雌激素依赖性疾病,其具体发病机制尚不明确。脂氧素是具有生物活性的花生四烯酸代谢产物,在子宫内膜及异位内膜中均有表达。其可以通过抑制中性粒细胞的聚集和化学趋化作用,增强巨噬细胞的吞噬功能而达到抗炎促炎症消退的效果,并能与雌激素受体结合、调节雌激素相关基因从而参与调控雌激素效应。脂氧素可同时参与炎症反应和雌激素效应的网络调控,有效抑制EMs的病灶生长。介绍了脂氧素的生理功能和研究现状,并综述脂氧素在EMs发生发展过程中的作用。
Endometriosis （EMs） has been well known as an inflammatory and estrogen-dependent disease. However,its aetiology and pathogenesis are still ambiguous. Lipoxins, one of the endogenous metabolites of arachidonic acid,present in both eutopic and ectopic endometrium. Lipoxins actively promote resolution by restricting the polymorphonuclear （PMN） accumulation at the sites of inflammation, and enhancing macrophage phagocytosis. It can also bind with estrogen receptor （ER）, and then modulate the expression of estrogen-related genes. Lipoxins can simultaneously modulate inflammation and estrogen signaling,and significantly inhibit the development of endometriosis. This article reviewed the biological function of lipoxins and its research progress, especially its role in the pathophysiology of EMs.
出处
《国际生殖健康／计划生育杂志》
CAS
2014年第1期56-59,共4页
Journal of International Reproductive Health/Family Planning
基金
厦门市科技计划项目(3502Z20134002)
福建省自然科学基金面上项目(2013D001)
