摘要
目的探讨超敏-C反应蛋白(hs-CRP)联合ABCD2评分对短暂性脑缺血发作(TIA)后7d内发生脑梗死(CI)的预测价值。方法共纳入120例TIA患者,依据发病后7d内是否发生CI分为CI组33例和非CI组87例。记录所有纳入对象的常见脑血管疾病危险因素、hs-CRP浓度水平及ABCD2评分。应用单因素分析CI组和非CI组间脑血管疾病危险因素、hs-CRP水平及ABCD2评分的差异性。进一步将所有患者以hs-CRP≤3mg/L和hs-CRP>3mg/L分两组,每组再根据ABCD2评分≤3分和>3分分为两组,以hs-CRP≤3mg/L且ABCD2评分≤3分组患者为基线组,余组分别与之比较,应用非条件Logistic回归单因素和多因素分析评价短期进展为CI的发生风险。应用受试者工作特征曲线(ROC)分析计算曲线下面积(AUC)评价hs-CRP、ABCD2评分和hs-CRP联合ABCD2评分预测CI的价值。结果 (1)基线资料单因素分析:CI组年龄〔(65.39±8.40)岁vs.(60.36±7.80)岁〕、hs-CRP水平〔(6.00±3.59)mg/L vs.(3.67±3.47)mg/L〕、ABCD2评分(4.64±1.27 vs.3.56±1.53)均高于非CI组(均P<0.05)。(2)Logistic回归结果:单因素分析和多因素分析显示hsCRP>3mg/L且ABCD2评分>3分组短期发生为CI的风险是基线组的10.843倍(95%CI为3.428~34.298,P<0.05)和13.546倍(95%CI为3.226~56.871,P<0.05)。(3)ROC分析结果显示,AUChs-CRP=0.75,AUCABCD2=0.71,AUChs-CRP+ABCD2=0.77,均P<0.05。结论 ABCD2是一种预测TIA后短期发生为CI的简单、有效的工具,将hs-CRP与ABCD2评分联合能提高对CI的预测价值。
Objective To explore the ability of high-sensitivity C-reactive protein （hs-CRP） combined with ABCD2 score in predicting the risk of transient ischemic attack （TIA） evolving into cerebral infarction （CI） within 7 days.Methods One hundred and twenty patients with TIA were collected.They were divided into the CI group （33 cases） and the non-CI group （87 cases） within 7 days from onset.The common cerebrovascular disease risk factors,hs-CRP level and ABCD2 score were recorded.Single factor analysis of cerebrovascular disease risk factors,hs-CRP level and ABCD2 score differences were used between the CI group and the non-CI group.According to hs-CRP level≤3 mg/L and ＞3 mg/L,all patients were further divided into two groups.Then according to ABCD2 score≤3 or 4-7,the two groups were respectively divided into two groups.Hs-CRP level≤3 mg/L and ABCD2 score≤3 group was the baseline group,other groups were respectively compared with the baseline group by unconditional single factor and multi-factor of logistic regression analysis to evaluate the risk of short-term progression to CI.Receiver operating characteristic curve （ROC） and calculation of the area under the curve （AUC） were applied to evaluated the performance of hs-CRP level,ABCD2 score and hs-CRP level combined with ABCD2 score in predicting CI.Results Single factor analysis of baseline data：in the CI group,age [（65.39±8.40） years old vs.（60.36±7.80） years old],hs-CRP level [（6.00±3.59） mg/L vs.（3.67±3.47） mg/L],and ABCD2 score （4.64 ± 1.27 vs.3.56 ± 1.53） were higher than the non-CI group,all differences had statistical significances （all P＜0.05）.Hs-CRP level combined with ABCD2 score of single factor logistic regression result showed hs-CRP level ＞ 3 mg/L and ABCD2 score 4-7 group＇ s short-term risk of progression to CI was 10.843 times higher than the baseline group （95％CI：3.428-34.298,P＜0.05）.Multifactor logistic regression analysis result also showed their risk of progression
出处
《中国神经免疫学和神经病学杂志》
CAS
北大核心
2014年第1期28-31,35,共5页
Chinese Journal of Neuroimmunology and Neurology
关键词
短暂性脑缺血发作
脑梗死
超敏-C反应蛋白
ABCD2评分
预测
transient ischemic attack
cerebral infarction
high-sensitivity C-reactive protein
ABCD2score
forecasting
