糖尿病大鼠肾脏p22phox的表达及普罗布考的干预研究被引量：2

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摘要研究证实氧化应激在糖尿病肾病的发生、发展中起重要作用，活性氧产物（ROS）在细胞外基质的聚集和肾小球硬化中起重要的信号传导作用，而还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶可通过诱导ROS的产生而导致。肾脏的氧化应激损伤，NADPH氧化酶亚基p22phox是其构成亚基之一，与酶的活性密切相关。本实验通过观察糖尿病大鼠肾脏中p22phox表达及断链抗氧化剂普罗布考对p22phox表达的影响，探讨其保护肾脏作用的机制。

作者季文萱刘桂美黄俊彦刘丽秋王雁飞

机构地区青岛市中心医院肾内科青岛大学医学院附属医院肾内科青岛大学医学院研究生院

出处《中华肾脏病杂志》 CAS CSCD 北大核心 2014年第1期56-59,共4页 Chinese Journal of Nephrology

基金基金项目：青岛市科技局资助项目（2012-1-3-4-（2）-nsh）

关键词 P22PHOX 糖尿病大鼠肾脏作用普罗布考还原型烟酰胺腺嘌呤二核苷酸 NADPH氧化酶氧化应激损伤糖尿病肾病

分类号 R587.2 [医药卫生—内分泌] R692 [医药卫生—内科学]

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