摘要
在回流条件下以乙醇为反应介质,醋酸铵为催化剂,三组分一锅法合成了2-氨基-4-芳基-5-氧代-5,6-二氢-4 H-吡喃并[3,2-c]吡啶-3-甲腈.该方法具有操作简单、反应条件温和、反应时间短等优点.
2-Amino-4-aryl-5-oxo-5,6-dihydro-4H-pyrano[3, 2-c] pyridine-3-carbonitriles have been synthesized by three-component one-pot condensation of aldehyde, pyridine-2,4-diol, and malononitrile in the presence of ammoni- um acetate in EtOH. This method has the advantages of operational simplicity, mild reaction conditions, short reac- tion time, and little environmental impact.
出处
《江苏师范大学学报（自然科学版）》
CAS
2013年第4期40-46,共7页
Journal of Jiangsu Normal University：Natural Science Edition
基金
Research supported by the National Natural Science Foundation of China(21104064,21172188)
Research Grant from the Innova-tion Project for Undergraduate of Jiangsu Province(2012JSSPIT3190)
Undergraduate of School of Chemistry&Chemical Engineering(HXKY2D201202)
