摘要
目的分析多发性骨髓瘤（multiplemyeloma，MM）患者合并肾功能衰竭的临床及血清免疫固定特点。方法回顾性分析四川省人民医院1999～2012年5月收治的213例MM患者的临床及实验室检查资料。‘结果150例（70．4％）合并肾损害患者中67例（44．6％）以肾损害为首发症状收入肾内科。92例（43．2％）合并肾功能衰竭患者中63例作血清免疫固定电泳，IgG20例（31．7％），IgA22例（34．9％），IgD1例（1．6％），单纯轻链型18例（28．6％）。与肾功能正常组相比，合并肾功能衰竭患者贫血、高钙血症、高尿酸血症以及免疫分型为单纯轻链型的发生率显著升高（P〈0．05）。结论MM合并肾功能衰竭的发生率高，免疫分型为单纯轻链型发生率高，临床症状重，提示肾科医师收治的中老年肾功能衰竭患者应注意排除MM．
Objective To investigate the clinical features of multiple myeloma（MM） patients with renal failure and understand the risk factors for MM with renal failure. Methods Clinical and laboratory data of 213 patients from January 1990 to May 2012 in Si- ehuan Provincial People＇s Hospital were retrospectively analyzed. Results There were 150 （ 150/213,70. 4% ） patients with renal im- pairment. Of the 150 cases, 67 cases （44. 6% ）were firstly diagnosed in Nephrology Department, There were 92 （92/213,43.2%） pa- tients with renal failure. Of the 92 patients, immune electrophoresis was performed in 63 cases, in which 20 cases （ 31.7% ） were IgG type,22 cases（34. 9% ）were IgA type,1 case（ 1.6% ）was IgD type and 18 cases（28.6% ）were pure light chain type. The rates of se- vere anemia, hypercaleemia and hyperurieemia in patients with renal failure were more frequent than that in the patients with normal re- nal function （ P 〈 0. 05 ）. Conclusion Renal failure was common in patients with multiple myeloma at the time of diagnosis, suggesting that nephrologists should pay attention to rule out multiple myeloma when treat the elderly patients with renal failure.
出处
《实用医院临床杂志》
2014年第1期78-80,共3页
Practical Journal of Clinical Medicine
