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儿童骨折患者血清骨代谢、血小板及氧化应激指标的变化研究 被引量:8

Change of serum bone metabolism,platelet and oxidative stress indexes of children with fracture
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摘要 目的:探讨儿童骨折患者血清骨代谢、血小板及氧化应激指标的变化情况。方珐:选取2011年8月-2013年6月于本院进行诊治的35例骨折患儿为观察组,并以同时期的35例健康儿童为对照组,比较观察组骨折后第l、3、7及14天和对照组的血清骨代谢、血小板及氧化应激指标水平。结果:观察组骨折后第1、3、7及14天的血清骨保护素(OPG)、降钙素(HCT)、胰岛素生长因子Ⅱ(IGF一11)及碱性磷酸酶(ALP)水平均高于对照组,骨折后第1、3、及7天血小板活性及血清丙二醛(MDA)水平均高于对照组,血清超氧化物歧化酶(SoD)、总抗氧化能力(TAC)及过氧化氢酶(CAT)均低于对照组,差异均有统计学意义(P均〈O.05),而骨折后第14天两组的血小板活性及氧化应激指标差异无统计学意义(P均〉0.05)。结论:儿童骨折患者血清骨代谢、血小板及氧化应激指标均呈现明显的波动,且不同时间均有一定的特点。 Objective: To investigate the change of serum bone metabolism,platelet and oxidative stress indexes of children with fracture. Methods:A total of 35 children with fracture in our hospital from August 2011 to June 2013 were se]ected as observation group,35 healthy children at the same time were se- lected as control group,then the serum bone metabolism, p|atelet and oxidative stress indexes of observa- tion group on the third, seventh and fourteenth day after the fracture and control group weredetermined.
出处 《海南医学院学报》 CAS 2014年第2期237-240,共4页 Journal of Hainan Medical University
基金 四川省卫生厅医学发展基金资助项目(201282772)~~
关键词 儿童骨折 血清 骨代谢 血小板 氧化应激 Children fracture Serum Bone metabolism Platelet Oxidative stress
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