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右美托咪定预防神经外科手术全麻苏醒期躁动的临床观察 被引量:40

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摘要 目的观察右美托咪定对神经外科手术全麻苏醒期躁动的预防作用。方法择期在全麻下行幕上脑肿瘤切除术患者40例,随机均分成两组:右美托咪定组(Dex组)和对照组,分别在脑膜缝合完毕后给予右美托咪定0.5μg/kg或同等容量的生理盐水,观察两组患者给Dex/生理盐水前、给药后、拔管即刻、拔管后3min、拔管后5min平均动脉压(MAP)和心率(HR),拔管时间和定向力恢复时间,躁动的发生情况,术后疼痛VAS评分。结果拔管即刻、拔管后3、5min Dex组的MAP和HR较对照组明显降低(P<0.05)。Dex组躁动评分及躁动的发生率低于对照组(P<0.05),拔管时间、定向力恢复时间与对照组相比差异无统计学意义(P>0.05),术后疼痛VAS评分Dex组低于对照组(P<0.05)。结论在神经外科手术结束前静注右美托咪定可有效减少全麻苏醒期躁动的发生。
出处 《重庆医学》 CAS CSCD 北大核心 2014年第1期120-121,共2页 Chongqing medicine
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