摘要
目的比较光动力疗法(photodynamic therapy,PDT)辅助龈下刮治术及根面平整术(scaling and root planing,SRP)和单独使用SRP治疗重度慢性牙周炎的临床疗效。方法对34例重度慢性牙周炎患者做自身对照,每个病人选取PD≥7 mm的位点,一共300个,随机分为实验组(SRP/PDT)和对照组(SRP)。实验组在龈下刮治术及根面平整术后做一次光动力治疗(光敏剂为26.7 mmol·L-1亚甲基蓝,660 nm激光),对照组仅行SRP。术前、术后1个月、3个月检查实验组及对照组的牙周探诊深度(probing depth,PD)和探诊出血(bleeding on probing,BOP)。结果实验组和对照组术前PD和BOP差异无统计学意义(P>0.05),术后1个月和3个月的结果显示,两组PD和BOP较术前均有改善,且实验组的PD和BOP改善效果均优于对照组,差异具有统计学意义(P<0.05)。结论对重度慢性牙周炎患者应用PDT辅助SRP治疗较单独使用SRP效果更佳。
Objective To compare the efficacy between photodynamic therapy （PDT） as an adjunctive treatment of severe chronic peri- odontitis with scaling and root planing in patients and treatment of SRP. Methods This is a split-mouth, randomized controlled clinical trial. A total of 300 sites, in which probing depth was not less than 7 mm, were selected from 34patients with severe chronic periodontitis. These sites were randomly assigned to SRP plus PDT using a laser source with a wavelength of 660 nm associated with 26.7 mmol · L- 1 methylene blue as the photosensitizer after SRP （test group） and the contra-lateral teeth were assigned to SRP only （control group）. Pro- bing depth （PD） and bleeding on probing （BOP） were recorded at baseline, 1 and 3 months after SRP. Results There was no statisti- cally significant difference in PD and BOP before periodontal treatment in both groups （ P 〉 0.05 ）. Clinical parameters improved signifi- cantly after both therapies,whereas higher reduction of PD and BOP were observed in the test group 1 and 3 months after SRP （P 〈 O. 05）. Conclusions Photodynamic therapy has an additional benefit to scaling and root planing when treating patients affected with se- vere chronic periodontitis.
出处
《安徽医药》
CAS
2013年第12期2075-2077,共3页
Anhui Medical and Pharmaceutical Journal
基金
安徽医科大学校基金资助项目(No 2011XKJ018)
