摘要
目的探讨儿童万古霉素血药浓度与不良反应的关系。方法收集235例使用万古霉素治疗并进行血药浓度监测的患儿病例资料,统计肝肾功能损伤、听力损伤发生的例数,分析不同范围万古霉素血药浓度与不良反应的相关性。结果不良反应总发生率为16.6%。主要发生的不良反应为肝功能损害及听力损害,发生率分别为9.4%、6.8%,均显著高于肾功能损害发生率。不同血药浓度病例组发生不良反应的频率、类型分布比较差异无统计学意义。万古霉素血药浓度水平对治疗前后肝肾功能无显著影响。结论在儿童,尤其是新生儿,应用万古霉素有较高的肝功能损害及听力损害发生率。不同范围血药浓度与肝肾损害、听力损伤3种不良反应无显著相关。
Objective To investigate the relationship of vancomycin serum concentration and drug adverse re- action （ADR） in children. Methods 235 children who were treated by vancomycin and had serum concentration monitor were recruited. The number of cases with liver, kidney and hearing damage after treatment was calculated. The correlation between serum concentration and ADRs was analyzed. Results The total incidence of ADRs was 16.6%. The main ADRs were liver damage（9.4% ）and hearing impairment（6.8% ） , and the rate of them were significantly higher than that of kidney damage. There was no significant difference in the ADR rates and distribution among the different serum concentrations groups. Vancomycin serum concentration had no significant influence on liver and kidney func- tion. Conclusion Children（ especially neonates） who were treated with vancomycin had relatively high rates of liver damage and hearing impairment. There was no significant correlation between vancomycin serum concentration and ADRs in children.
出处
《实用药物与临床》
CAS
2013年第12期1200-1203,共4页
Practical Pharmacy and Clinical Remedies
关键词
儿童
万古霉素
血药浓度
不良反应
Children
Vancomycin
Serum concentration
Adverse reaction
