摘要
目的了解浏阳市人民医院2008~2012年大肠埃希菌在临床标本中的分离情况及其耐药趋势,为临床感染的预防和治疗提供参考资料。方法收集2008~2012年各种标本中分离出的所有大肠埃希菌,用Phoenix-100鉴定仪鉴定,药敏试验采用K-B纸片扩散法。结果 2 901株大肠埃希菌中产超广谱β-内酰胺酶菌株阳性率高达39.4%~45.6%。大肠埃希菌对亚胺培南、美罗培南、阿米卡星、哌拉西林/他唑巴坦和头孢哌酮/舒巴坦的耐药率小于20.0%;对氨苄西林、头孢唑啉和哌拉西林的耐药率大于70.0%。结论临床标本分离大肠埃希菌耐药率和耐药性逐年增强,临床医生应该重视病原菌的培养和药敏试验,根据药敏结果合理应用抗菌药物。
Objective To study the isolation of Escherichia coli （E.coli） in the clinical specimen and its drug-resistance tendency from 2008 to 2012 in Liuyang Municipal People＇s Hospital, so as to provide valuable data for infection prevention and treatment. Methods All the E.coli isolated from all kinds of clinical specimens from January 2008 to 2012 were collected. Phoenix-100 Micro Scan was used for identification,and the K-B method was adopted for drug sensitive test. Results In the 2 901 strains of E.coli, the positive rate of extended spectrum beta-lactamases （ESBLs） reached to 39.4%--45.6%. Drug-resistance rate of E.coli to Imipenem, meropenem, Amikacin, piperacillin/tazobactam and Cefoperazone/Sulbactam was less than 20%, while the drug-resis^nce rate to ampicillin,Cefazolin and piperacillin was higher than 70.0%. Conclusion The drug-resistance rate and drug resistance of E.coli isolated from clinical specimen grows year by year. The clinician should pay attention to the cultivation of the pathogen and drug sensitivity test, and the reasonable application of antibiotics is conducted on the basis of susceptibility testing.
出处
《现代医药卫生》
2014年第1期43-44,共2页
Journal of Modern Medicine & Health
关键词
大肠杆菌
抗药性
细菌
抗菌药
微生物敏感性试验
药物耐受性
Escherichia coli
Drug resistance,bacterial
Anti-bacterial agents
Microbial sensitivity tests
Drug tolerance
