摘要
在非兴奋型细胞中，钙库调控性钙通道（SOCC）是胞外钙离子进入胞内的最主要途径，可调控多种肿瘤细胞的生物学特性，包括黏附、分泌、运动、基因表达、增殖、分裂与凋亡等。基质交联分子1（STIMl）和Orail是SOCC的重要组成部分，故过表达或抑制表达STIMI／Orail可调控SOCC活性和肿瘤细胞的生物学特性。而SOCC对肿瘤细胞的作用却自相矛盾，既可促进肿瘤进展，又可抑制肿瘤进展。SOCC有望成为治疗肿瘤的一个新靶点，但其机制复杂，既需考虑肿瘤细胞类型，还需考虑外界刺激因子对肿瘤细胞的作用。
In most non-excitable cells, the store-operated calcium channel （SOCC） in the plasma membrane is the major calcium entry pathway. SOCC plays an important role in calcium signals that control many cancer cellular processes such as adhesion, secretion, movement, gene expression, proliferation, division and apoptosis. Stromal interaction molecule 1 （STIM1） and Orail are the two important parts of SOCC. So overexpression or suppression expression of STIM1/0rail can regulate SOCC activity and biological characteris- tics of cancer cells. However, SOCC plays a contradictory role in cancer ceils, which can both promote tumor progression and inhibit tumor progression. SOCC is expected to become a new target for the treatment of tumors, but its complicated mechanism needs to consider both types of tumor cells and the external stimulators of tumor cells.
出处
《国际肿瘤学杂志》
CAS
2013年第11期814-816,共3页
Journal of International Oncology
关键词
钙通道
肿瘤
生物学现象
Calcium channels
Neoplasms
Biological phenomena
