摘要
目的分析2012年北京市密云县健康人群乙型脑炎抗体水平特征及影响因素。方法按照随机抽样的方法抽取密云县10个行政村（居委会）作为调查点,选择在当地连续居住6个月以上的健康人群共268人,采用反向被动血凝抑制方法测定乙脑中和抗体,抗体滴度≥1∶10判断阳性。结果健康人群乙脑抗体监测阳性率为68.28%,其中0岁~组抗体阳性率最低为12.00%,1岁~组抗体阳性率最高,为100%,不同年龄组抗体阳性率差异有统计学意义（χ2=68.731,P=0.000）;不同户籍抗体阳性率分别为72.06%和64.39%;不同免疫次数人群乙脑抗体阳性率差异有统计学意义（χ2=55.919,P=0.000）结论该县有可能发生乙脑流行,主要是因为0岁~,25岁~年龄组的抗体水平偏低,此结果提示应探讨育龄期妇女及成人乙脑疫苗免疫策略,同时应做好防蚊灭蚊工作,防止乙脑流行。
Objective To analyze the characteristics of Japanese encephalitis（ JE） antibody level and its influence factors in healthy population in Miyun County in 2012. Methods Random sampling method was used in this study. Total 268 healthy persons who came from 10 administrative villages and lived there continuously over 6 months were selected. Neutralizing antibodies to Japanese encephalitis virus（ JEV） were detected by Reverse Passive Hemagglutination Inhibition test. The antibody levels with or higher than 1∶10 were judged to be positive. Results The positive rate of JE antibody was 68. 28% in healthy population. Among them,there were significant differences between different age groups（ χ2= 68. 731,P = 0. 000）. The positive rate in 0-year old group was the lowest（ 12. 00%） and the rate in 1 to 4-year old group was the highest（ 100. 00%）. The rates of positive in local residents and migrants were 72. 06% and 64. 39% respectively. Meanwhile,the positive rates were also statistically different in persons with different doses of JE vaccination（ χ2= 55. 919,P = 0. 000）. Conclusion The epidemic of JE might occur in Miyun County due to the low antibody levels of persons in 0 year old and 25- 29 years old groups. The results suggested immunization strategies for women of childbearing age and adult should be explored. At the same time,mosquito control also should be enhanced to prevent the epidemic of JE.
出处
《首都公共卫生》
2013年第6期259-261,共3页
Capital Journal of Public Health
关键词
乙脑
抗体水平
阳性率
Japanese encephalitis
Antibody level
Positive rate
