摘要
目的分析进展性脑卒中与C反应蛋白(CRP)及颈动脉斑块性质的相关性。方法将106例首次发病的急性前循环脑梗死患者根据病情进展情况分为进展组28例和非进展组78例,同时选择同期28例病房内非卒中,且无动脉粥样硬化的基础患者作为对照组。根据超声学特征及斑块形态,将脑梗死患者分为无斑块、稳定斑块和不稳定斑块患者,并应用免疫比浊法测定3组CRP水平。结果发病72 h时,进展组国立卫生研究院卒中量表(NIHSS)评分明显高于非进展组;进展组斑块发生以不稳定斑块为主,而非进展组斑块发生以稳定斑块为主;进展组与非进展组患者CRP水平明显高于对照组,且进展组升高幅度显著大于非进展组;稳定斑块和不稳定斑块患者CRP水平明显高于对照组,且不稳定斑块患者升高幅度显著大于稳定斑块患者。结论进展性脑卒中的发生与CRP水平升高和颈动脉斑块的不稳定性具有显著相关性。
Objective To analyze the correlation between progression cerebral infarction and C- reactive protein （CRP） as well as carotid plaque nature. Methods According to the condition of pathological progression, 106 patients with primary acute anterior circulation of cerebral infarction were divided into progressive group （ n = 28） and non - progressive group （ n = 78）. Meanwhile, 28 patients without stoke and atheroselerosis were selected and designed as control group. Based on ul- trasound characteristics and plaque morphology, the patients with cerebral infarction were divided into 3 categories： no plaques, stable plaques and unstable plaques. Immunoturbidimetry was used to detect CRP level in all the groups. Results National Institutes of Health Stroke Scale （NIHSS） score in progressive group was significantly higher than that in the non- progressive group at the time of 72 hours after onset. The unstable plaques was the main manifestation in the progressive group, while the stale plaques was the main manifestation in the non- progressive group. Level of CRP in both progressive and non- progressive groups were significantly higher than the control group, and the increased range in the progressive group was larger. Level of CRP in patients with stable and unstable plaques were significantly higher than those in the control group, and the increased range in patients with unstable plaques was larger. Conclusion Occurrence of progressive cerebral infarction is significantly related to increased CRP level and the stability of carotid plaques.
出处
《实用临床医药杂志》
CAS
2013年第23期15-18,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321234)
关键词
进展性脑卒中
C反应蛋白
颈动脉斑块
免疫比浊法
progressive cerebral infarction
C- reactive protein
carotid plaques
im- munoturbidimetry
