摘要
目的探讨原发性干燥综合征周围神经病变的发生与干燥综合征A型/B型抗体(抗SSA/SSB抗体)的关系。方法纳入2009年1月-2011年12月期间门诊及住院收治的原发性干燥综合征患者88例。所有患者均接受神经系统检查,采用蛋白质印迹法检测抗SSA抗体和抗SSB抗体,利用全自动化学发光仪检测血清维生素B12水平。结果 88例原发性干燥综合征患者中有27例(30.7%)存在周围神经病变。有或无周围神经病变的患者在年龄、性别、病程等一般情况方面无明显不同。有周围神经病变和无周围神经病变的原发性干燥综合征患者抗SSA抗体阳性率分别为70.4%(19/27)、70.5%(43/61),差异无统计学意义(χ2=0.000,P=0.991);抗SSA/SSB抗体双阳性率分别为63.0%(17/27)、14.8%(9/61),差异有统计学意义(χ2=17.416,P=0.000);血清维生素B12水平分别为(390±55)、(410±86)pg/dL,差异无统计学意义(t=0.908,P=0.370)。结论周围神经病变在原发性干燥综合征患者中较常见,且周围神经病变的发生多伴随血清抗SSA/SSB抗体阳性。
Objective To investigate the relationship between peripheral neuropathy and anti-SSA/anti-SSB in patients with primary sjogren syndrome （pSS）. Methods Eighty-eight patients with pSS were screened and underwent a neurological examination between January 2009 and December 2011. Anti-SSA and anti-SSB antibodies were determined by immunoblotting, and serum vitamin B±2 levels were determined by automatic chemiluminescence analyzer. Results In this cohort, 30.7% （27/88） of the patients had peripheral neuropathy, and age, sex and course of disease were all similar between patients with and without neuropathy. The difference in rate of positive anti-SSA between neuropathy patients with neuropathy and without neuropathy was not significant [70.4% （19/27） vs. 70.5% （43/61）; X2=0.000, P=0.991]; but the difference in anti-SSA/anti-SSB between pSS patients with neuropathy and without neuropathy was significant [63.0% （17/27） vs. 14.8% （9/61）; X2=17.416, P=-0.000]. In addition, there was no association of serum vitamin B12 levels to neuropathy [（390 ± 55）, （410 ± 86） pg/dL; t=0.908, P=0.370]. Conclusion Peripheral neuropathy is common among patients with pSS and is associated with the presence of anti-SSA and anti-SSB.
出处
《华西医学》
CAS
2013年第12期1862-1864,共3页
West China Medical Journal
