摘要
目的比较西地那非与硫酸镁治疗新生儿持续肺动脉高压(PPHN)的临床疗效,探讨治疗PPHN的最适药物治疗措施。方法选择80例PPHN患儿,在患儿家属知情同意的情况下分为西地那非组(n=40例)和硫酸镁组(n=40例),分别给予西地那非与硫酸镁治疗,比较两组患儿治疗中肺动脉压力(SPAP)、动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、体循环收缩压(SBP)的动态变化以及治疗3 d后的临床疗效。结果两组患儿治疗后病情均有明显好转,西地那非比硫酸镁更快改善CO2潴留,治疗6～12 h时和治疗24～48 h时组间平均PaCO2比较差异具有统计学意义(P<0.05);硫酸镁组出现降低体循环压力的副作用,治疗6～12 h时和治疗24～48 h时组间平均SBP比较差异具有(高度)统计学意义(P<0.05,P<0.01);治疗3 d后两组治愈与无效例数比较,差异均具有统计学意义(P<0.05),西地那非组优于硫酸镁组。结论治疗PPHN时应首选西地那非,与硫酸镁相比其更安全有效。
Objective To compare the clinical effect of sildenafil and magnesium sulfate in the treatment of persistent pulmonary hypertension of newborn （PPHN） and research into the optimal drug treatment measures. Method Collect 80 children with PPHN, they were divided into sildenafil group（ n = 40 cases） and magnesium sulfate group（ n = 40 cases）, compared with the dynamic changes of pulmonary artery pressure （ SPAP）, arterial blood oxygen partial pressure （ PaO2）, carbon dioxide partial pressure （PaCO2）, circulation systolic blood pressure （SBP） in the treatment and the clinical effect after three days＇ treatment. Results The children＇s condition was significantly improved after the treatment, CO2 retention in the sildenafil group was im- proved faster than that in magnesium sulfate group, there was significant（ P 〈 0.05） after 6 - 12 h and 24 - 48 h treatment; Mag- nesium sulfate group appeard to reduce the side effects of systemic pressure, there was （highly） significant（ P 〈 0.05, P 〈 0.01） after 6 - 12 h and 24 - 48 h treatment; there was significant（ P 〈 0. 05） in the clinical effect after three days＇ treatment, the silde- nafil group was better than the magnesium sulfate group. Conclusion We should choose sildenafil to treat PPHN first. Compared with the magnesium sulfate, it was more safe and effective.
出处
《中国地方病防治》
2013年第6期465-467,共3页
Chinese Journal of Control of Endemic Diseases
关键词
西地那非
硫酸镁
新生儿持续肺动脉高压
临床疗效
Sildenafil
Magnesium sulfate
Persistent pulmonary hypertension of newborn
Clinical effect
