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卵巢早衰和线粒体功能障碍 被引量:9

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摘要 卵巢早衰(prematureovarian failure,POF)是指女性在40岁以前发生的自然绝经。一般认为人群POF发生率为1%~3%,闭经患者中2%~10%为卵巢早衰。POF发病年龄取决于卵巢中原始卵泡的储备及出生后卵泡闭锁的速度。卵泡储备少及闭锁速度快都会使卵巢功能提前衰竭。卵巢早衰的病因复杂,研究显示卵巢早衰患者线粒体DNA含量比正常人的低心]。在卵巢早衰患者外周血细胞线粒体DNA含量比同年龄卵巢储备完整者显著下降。
出处 《中国妇幼保健》 CAS 北大核心 2014年第2期311-314,共4页 Maternal and Child Health Care of China
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