摘要
目的探讨五味子、红景天苷及复方五味子对军事应激前后人体下丘脑-垂体-肾上腺(HPA)轴、下丘脑-垂体-睾丸(HPG)轴和血清IL-1、IL-2、IL-6基础水平的影响。方法选择120名未经过较长期两栖作战训练的健康基层步兵作战部队官兵,随机分为复方五味子组(A组)、五味子组(B组)、红景天苷组(C组)、对照组(D组),每组30名。4组均进行每日8h的高强度复合军事训练,共持续1周。分别在训练前日和训练结束后次日清晨(7:00-8:00)静脉采血,采用放射性免疫分析法测定血清促肾上腺皮质激素(ACTH)、皮质醇(CORT)、睾酮(T)、IL-1、IL-2、IL-6水平并进行组间比较。结果对照组中,训练后的血清CORT和ACTH基础水平与训练前比较无明显差异(P>0.05),而T水平明显下降(P<0.01),IL-2水平明显上升(P<0.05),IL-6水平明显下降(P<0.01),IL-1水平比训练前亦有所升高,但差异无统计学意义。五味子组中,训练后的ACTH、T及IL-6水平较训练前明显下降,而IL-2水平明显升高(P<0.01),CORT有下降趋势,但差异无统计学意义(P>0.05)。红景天苷组中,训练后的T水平及IL-6水平较训练前明显下降(P<0.01),CORT有下降趋势,但差异无统计学意义(P>0.05)。复方五味子组中,训练之后的血清CORT、ACTH、T水平及IL-1、IL-6水平均明显下降,而IL-2水平明显升高(P<0.01)。训练前各组之间各激素与细胞因子水平差异均无统计学意义(P>0.05)。训练后五味子组和复方五味子组血清ACTH水平及红景天苷组血清IL-2水平与对照组比较明显下降(P<0.05)。结论五味子及复方五味子对应激后HPA轴的抑制作用显著而持久,减弱了应激反应导致的CORT和ACTH水平升高,五味子复方中药可减轻应激导致的HPG轴的抑制,而红景天苷能明显减弱应激引起的IL-2水平升高。
Objective To explore the changes in basic serum levels of hypothalamus-pituitrin-adrenal （HPA） axis, hypothalamus-pituitrin-gonad （HPG） axis and proinflammatory cytokines IL-1, IL-2 and IL-6 in repeated acute stress caused by one-week intensive training, and study the effects of oral administration of Schisandrae, salidroside and Schisandrae compound on the contents of those stress hormones and cytokines mentioned above. Methods One hundred and twenty healthy soldiers chosen from junior infantry combat troops who had never received long-term amphibious training were randomly divided into four groups （30 each）： group A （Schisandrae compound group）, group B （Schisandrae group）, group C （salidroside group） and group D （control group）. Each and every soldier of all the groups underwent high-intensity composite military training, 8 hours per day, for a week. Venous blood sampling was collected at 7：00-8：00 a.m. before and after the training, respectively. Levels of cortisol （CORT）, adrenocorticotropic hormone （ACTH）, testosterone （T）, IL-I, IL-2 and IL-6 in different groups were measured by radioimmunoassay （RIA）. The changes in the levels of all the above mentioned hormones and cytokines in every group were observed and compared. Results In group D, as compared with the pre-stress levels, no marked difference was found in the levels of serum CORT and ACTH （P〉O.05）, but the levels of T and IL-6 significantly decreased （P〈0.01）, and that of IL-2 significantly increased （P〈0.05）, while that of IL-1 slightly increased, but without statistical significance. In group B, the levels of ACTH, T and IL-6 significantly decreased after the training, and that of IL-2 elevated （P〈0.01）, while that of CORT slightly decreased without statistical significance （P〉0.05）. In group C, the levels ofT and IL-6 significantly decreased （P〈0.01） when compared with the pre
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2014年第1期65-69,共5页
Medical Journal of Chinese People's Liberation Army
基金
全军"十二五"科研基金面上项目(CWS11J252)~~
关键词
五味子
红景天苷
高强度训练
应激激素
白细胞介素类
Schisandra chinensis
salidroside
high-intensity training
stress hormones
interleukins
