摘要
目的观察麻牛止嗽颗粒治疗感染后咳嗽的疗效和安全性。方法选择感染后咳嗽患者200例,采用随机单盲方法分为两组,研究组100例患者给予麻牛止嗽颗粒治疗,对照组100例患者给予复方甘草口服溶液,疗程均为7 d,比较两组治疗前后症状体征改善情况、咳嗽对生活质量的影响、实验室常规指标变化,同时比较两组疗效与不良反应。结果两组治疗前咳嗽次数、程度、咽痒、咯痰症状评分比较差异无统计学意义(P>0.05)。治疗后研究组各症状评分明显低于对照组(P<0.05)。研究组总有效率明显优于对照组(P<0.05),研究组治疗效果明显好于对照组,研究组治疗后LCQ评分提高幅度明显大于对照组,咳嗽敏感性阈值(C5)浓度高于对照组,两组比较差异具有统计学意义(P<0.05)。结论麻牛止嗽颗粒可修复感染所致呼吸道上皮细胞损伤,减轻呼吸道炎症,降低气道反应性,缓解症状,是治疗感染后咳嗽的有效药物。
Objective： To observe the efficacy and safety of Maniuzhisou Granule in the treatment of cough after infection. Methods： 200 cases of infectious cough patients used the randomized single blind method were divided into two groups. 100 cases of study group were treated by Maniuzhisou Granule. 100 cases in the control group were treated by compound glycyrrhiza oral solution for 7d. There were some indices compared 2 groups before and after treatment including the signs and symptoms improvments,the cough effect on quality of life, the routine labo- ratory indices changes and then,these indices were compared such as the curative effects and the adverse reac- tions. Results： Compared with 2 groups ,before the treatment, the frequency of cough and degree and the sputum itching symptom score had no significant differences.After the treatment sputum itching symptom score of study group was lower than that of the control group（P〈 0.05）. The total efficiency of study group was better than that of the control group （P〈 0.05）. The treatment effect of study group was better than that of the control group after treatment. The LCQ score of the study group was significantly larger than that of the control group. The cough sensitivity threshold （C5） of the study group was higher than that of the control group. Conclusion： Maniuzhisou Granule can repair the respiratory epithelial cell injury induced by infection. Also, It can reduce airway inflamma- tion, reactivity and relieve symptoms. It is an effective drug in treating cough after infection.
出处
《中国中医急症》
2013年第12期2017-2018,2034,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
广西壮族自治区中医药管理局科研课题(gzzc1035)
关键词
麻牛止嗽颗粒
感染后咳嗽
机制
疗效
Maniuzhisou Granule
Cough after infection
Mechanism
Curative effect
