摘要
目的评价慷舒灵凝胶治疗浅Ⅱ度烧伤创面的临床有效性、安全性及抗菌作用。方法 90例浅Ⅱ度烧伤创面患者,随机分为慷舒灵凝胶试验组和磺胺嘧银软膏对照组各45例。观察两组的创缘反应、疗效性指标(治疗第5、7、10、14天的创面愈合百分率、创面100%愈合时间和创面判断)、细菌培养+药敏实验以及安全性指标。结果试验组创缘反应较对照组轻;安全性较对照组高;治疗效果评价:除治疗第5天外,治疗第7、10、14天试验组治疗有效率高于对照组(P<0.05);两组创面100%愈合时间相比较,试验组少于对照组(P<0.05);治疗第7天创面感染率比较,试验组低于对照组(P<0.05)。结论慷舒灵凝胶能降低浅Ⅱ度烧伤创面的感染率,减少局部不良反应,促进创面愈合,治疗效果明显优于磺胺嘧啶银软膏。
Objective To evaluate the clinical effect, safety and antibacterial property of SilvaSorb gel in the treatment of superficial II degree bum wounds. Methods Ninety patients were divided equally and randomly in- to two groups, and each group had 45 patients： SilvaSorb gel experimental group and Silver sulfadiazine cream control group. Reaction of the edge of wound, index of the effect （the percentage of healing effect, 100% healing time and wound decision at 5~, 7~, 10＊, and 14~ day after treating）, bacteria culture and drug sensitivity test, and the index of drug safety were observed. Results The reactions of the edge of wound of the experimental group were less than that of the control group, the safety of the experimental group was higher than that of the control group. Compared with the control group, the effective rate of the experimental group were not significantly higher at 5~ day after treating, the effective rate of the experimental group were significantly higher at 7~, 10~, 144 day after treating （P〈0.05）, the 100% healing time of the experimental group was significantly shorter （P〈0.05）, the infection rate of the experimental group was significantly lower （P〈0.05）. Conclusion SilvaSorb gel can depress wound infection rate, decrease adverse reactions, accelerate wound healing, and the effect of SilvaSorb gel is superior to that of Silver sulfadiazine cream.
出处
《海南医学》
CAS
2013年第24期3627-3630,共4页
Hainan Medical Journal
基金
深圳市南山区科技计划项目(编号:南卫2008038)
关键词
慷舒灵凝胶
磺胺嘧银软膏
创面
感染
SilvaSorb gel
Silver sulfadiazine cream
Wound
Infection
