摘要
目的:观察托吡酯治疗甲基苯丙胺依赖者的疗效及不良反应。方法:将67例患者随机分成研究组(小剂量利培酮+含托吡酯A胶囊)34例和对照组(小剂量利培酮+安慰剂B胶囊)33例进行双盲对照。于治疗前、治疗1、2、4和6周后采用外显攻击行为量表(MOAS)、焦虑自评量表(SAS)和自拟心理渴求量表(PCS)评价治疗效果。结果:控制了吸食时间和剂量这两个变量以后,组效应和治疗时间效应:MOAS评分(F=705.10,P<0.01;F=694.95,P<0.01)、SAS评分(F=491.54,P<0.01;F=833.73,P<0.01)、PCS评分(F=125.25,P<0.01;F=411.39,P<0.01)差异有统计学意义。同时组别和治疗时间之间有明显的交互效应:MOAS评分(F=54.23,P<0.01)、SAS评分(F=41.38,P<0.01)、PCS评分(F=11.09,P<0.01),差异有统计学意义。结论:托吡酯合并小剂量利培酮能够改善甲基苯丙胺依赖者的激惹行为,稳定情绪,降低心理渴求。
Objective： To observe the therapeutic ettect and adverse reaction ot toplramate on metham- phetamine dependence. Method：The research was conducted in the form of double-blind placebo-controlled trial. Sixty-seven patients were randomly divided into a study group （given capsule A containing topiramate and small doses risperidone） with 34 cases and a control group （given capsule B containing placebo and small doses risperidone） with 33 cases respectively. The effectiveness of therapy was evaluated before treatment and 1,2,4, 6 weeks after the treatment with modified overt aggression scales （MOAS） , self-rating anxiety scale （SAS） and psychological craving scale （PCS）. Results：After controlling the time and dose of methamphetamine use, sig- nificant drug effect and treatment time effect were observed in MOAS（ F = 705. 10 ,P 〈 0. 01 ; F = 694. 95 ,P 〈 0.01） ,SAS（F=491.54,P 〈0. 01 ;F=833.73,P 〈0.01） ,and PCS（F = 125.25,P 〈0. 01 ;F =411.39,P 〈 0.01 ）,respectively, significant interaction effects between treatment drug and time were also found in MOAS （F=54.23,P〈0.01）,SAS（F=41.38,P〈0.01）and PCS（F = 11, 09,P 〈0.01）. Conclusion： Topira- mate combined with small doses of risperidone can improve the irritable behavior, stabilize the emotion and re- duce the psychological craving of methamphetamine dependence.
出处
《临床精神医学杂志》
2013年第6期387-389,共3页
Journal of Clinical Psychiatry
关键词
托吡酯
利培酮
甲基苯丙胺依赖
topiramate
risperidone
methamphetamine dependence
