摘要
目的回顾性分析甲型肝炎重症化临床特征。方法收集我院2002年1月至2012年12月收治的525例甲型肝炎患者资料，分析甲型肝炎重症化原因及转归等。结果甲型肝炎患者525例，其中普通甲型肝炎512例（512／525，97．52％），肝衰竭患者共13例（13／525，2．48％），两组平均年龄分别为（30．58±14．68）岁及（40．15±11．37）岁（P〈0．01）。单纯感染甲型肝炎417例中发生肝衰竭患者4例（0．96％），重叠感染患者108例中发生肝衰竭9例（8．33％），两组比较x^2=16．38，P=0．0001。13例肝衰竭患者TBil峰值平均（384．48±130．41）μmol／L；PA峰值平均25．95％±10．36％。肝衰竭合并肝性脑病、肝肾综合征患者无效死亡率均100％。结论甲型肝炎重症化较少，主要见于重叠感染患者，有乙型肝炎肝硬化基础、晚期或伴随严重并发症患者预后较差。
Objective To study the clinical features of severe hepatitis A in China. Methods The clinical data of 525 patients with hepatitis A were retrospective analyzed from 2002 to 2012. The causes and outcomes of these patients were further investigated. Results Among 525 cases,512 cases had hepatitis A（512/525,97.52% ） ,13 cases had liver failure （13/525,2.48%）. The average age of hepatitis A group and liver failure group were 30.58 ± 14.68 and 40. 15 ± 11.37, respectively（ P 〈 0. 01 ）. The frequency of liver failure in superinfection group was higher than that of simple hepatitis A group （X2 = 16.38, P = 0. 0001）. In 13 liver failure cases, the average level of peak Tbil was （384.48 ± 130. 41 ） μmol/L, the average level of prothrombin activity（PTA） was 25.95% ± 10. 36%. All the patients with the complication of hepatic coma and hepatorena] syndrome were deteriorated. Conclusion Severe hepatitis A is a disease with low prevalence in China,caused mainly by superinfection. The prognosis may be poor in patients with cirrhosis, later stage, liver cirrhosis or serious complications.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2013年第6期467-468,共2页
Chinese Journal of Experimental and Clinical Virology
