摘要
目的探讨真性小眼球患者眼底改变及其相干光断层扫描（OCT）图像特点。方法回顾性系列病例研究。收集2008年6月至2010年12月在中山大学中山眼科中心就诊的12例（23只眼）真性小眼球（眼轴≤20．0mm）患者的临床资料，及与其年龄和性别匹配的23名（23只眼）健康人资料。行常规眼部检查、眼压测量、眼轴测定、前房深度测量、屈光度检查、免散瞳眼底照相及频域相干光断层扫描（SD—OCT）检查；分析真性小眼球患者的视网膜和视乳头的OCT图像特征。采用独立样本t检验比较健康人与真性小眼球者视网膜厚度的差异，以及真性小眼球继发青光眼和无青光眼患者视网膜厚度的差异。采用Pearson相关分析法分析眼轴与视网膜厚度的相关性。结果12例真性小眼球患者平均年龄（25．0±13．1）岁，平均眼轴（17．30士1．66）mm。t3只眼继发青光眼，平均眼压为（28．62±9．18）mmHg（1mmHg=0．133kPa）；10只未继发青光眼者平均眼压为（14．96±3．21）mmHg。OCT图像显示，真性小眼球患者黄斑中心凹视网膜厚度均增厚，中心凹处可见不同程度的神经纤维层、节细胞层、内丛状层、内核层和外丛状层，外核层增宽；5只眼黄斑区视网膜局部褶皱形成突向玻璃体腔，视网膜内小囊形成；3只眼后极部视网膜神经上皮层浆液性浅脱离，其中2只眼浅脱离下方视网膜色素上皮散在点状小突起。10只单纯真性小眼球眼和4只继发早期青光眼者视乳头呈拥挤状，周围视网膜增厚，9只继发晚期青光眼者则表现为视杯扩大加深。真性小眼球平均黄斑中心凹视网膜厚度[（335．65±91．45）斗m]较健康人[（192．72±11．18）肛m]明显增加（t=10．50，P=0．000）；继发青光眼者的平均黄斑中心凹视网膜厚度[（323．70±104．09）μm]较单纯真性小眼球者[（403．50±130．24）恤m]薄；23只眼黄斑中心凹�
Objective To observe the fundus features of nanophthalmos with or without secondary glaucoma using spectral domain optical coherence tomography （SD-OCT）. Methods It was a retrospective case-series study. Twenty-three eyes of 12 patients （6 female, 6 male） who were clinically identified to be nanophthalmos（ axial length~〈20.0 mm） in Zhongshan Ophthalmic Center from June 2008 to December 2010 and twenty-three eyes of 23 age and sex matched normal controls were included in this study. All patients underwent ophthalmological examinations including best-corrected visual acuity, refraction, slit-lamp biomicroscopy and fundus examination, Goldmann applanation tonometry, A-scan and B-scan ultrasound examinations, ultrasound biomicroscopy, fundus photography and spectral domain optical coherence tomography（SD-OCT）. All examinations were carried out with natural pupil. The fundus features detected by OCT were compared between nanophthalmos and normal controls, and among nanophthalmos with or without secondary glaucoma. Independent-samples t test was used to analyze the difference of retinal thickness between nanophthalmoic eyes and controls and also between nanophthalmoic eyes with and without secondary glaucoma. Pearson correlation analysis was used to analyze the correlation between axial length and macular retinal thickness. Results The average age of 12 patients was （ 25.0 ＋ 13. 1 ） years, and the mean axial length was （ 17.30 ＋ 1.66） mm. Thirteen eyes suffered from secondary glaucoma because of angle closure with average intraocular pressure（IOP） of （28.62 -＋ 9.18） mm Hg（ 1 mm Hg = O. 133 kPa）. The average IOP of the other 10 eyes without secondary glaucoma was （ 14. 96 -＋ 3.21 ） mm Hg. OCT images revealed thickening of the retina in macular fovea, with residual retinal nerve fiber layer, ganglion cell layer, inner plexiform layer,inner nuclear layer, outer plexiform layer, and broadened outer nuclear layer in 23 eyes with nanophthalmos. Pre-retinal folds were seen in
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2013年第12期1069-1074,共6页
Chinese Journal of Ophthalmology
基金
广东省自然科学基金（2011010006046）
关键词
小眼
眼底
体层摄影术
光学相干
Microphthalmos
Fundus oculi
Tomography, optical coherence
