摘要
目的检测结核性胸膜炎患者血清中白细胞介素-2受体(IL-2R)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)浓度的变化,探讨三者与结核性胸膜炎临床表现的相互关系及其临床意义。方法采用酶联免疫吸附试验对50例结核性胸膜炎患者(实验组)治疗前后以及40例健康体检者(对照组)血清IL-2R、TNF-α和PCT浓度进行检测。结果结核性胸膜炎患者血清中IL-2R、TNF-α和PCT浓度显著高于对照组,差异有统计学意义(P<0.01);治疗后恢复期三者浓度明显下降,但仍高于对照组,差异无统计学意义(P>0.05)。结论 IL-2R、TNF-α和PCT在结核性胸膜炎的发生和发展过程中起重要作用,可以作为诊断结核性胸膜炎的重要依据之一,对结核性胸膜炎的临床治疗和预后也有一定临床实用价值。
Objective To investigate the changes of concentration of interlukin-2 reeeptor（IL-2R）,tumor nec- rosis factor-α（TNF-α） and procalcitonin（PCT） in patients with tuberculous pleurisy, to explore the relationship be- tween these detections with clinical symtoms. Methods Fifty patients diagnosed as tuberculous pleurisy were chosen as test group,and the serum concentrations of IL-2R,TNF-α and PCT in these patients were measured by the method of enzyme - linked immunosobent assay（ELISA）, both before and after the treatment. Forty healthy people were cho- sen as control group,and their serum concentrations of IL-2R,TNF-α and PCT were also detected by ELISA. Results The serum concentrations of IL-2R,TNF-α and PCT in patients with tuberculous pleurisy before treatment were sig- nificantly higher than those in normal control group（P〈0. 01） ;after the treatment,there was no difference in the se- rum concentrations of IL-2R, TNF-α and PCT between these patients in experimental group and those in healthy con- trol group（P〈0.05）. Conclusion IL-2R,TNF-α and PCT play an important role in the pathogenesis of tuberculous pleurisy, and they could be one of the most important diagnostic evidences, and they also have clinical values for the treatment and prognosis of this disease.
出处
《检验医学与临床》
CAS
2013年第23期3146-3147,共2页
Laboratory Medicine and Clinic
