摘要
补体系统是机体固有免疫系统的重要组成部分,中枢神经系统的神经元、星形胶质细胞及小胶质细胞可以产生几乎所有的补体系统组分,表达各种补体受体。神经科学研究发现,补体系统在中枢神经系统正常功能及一些疾病中都有重要的作用。补体广泛参与神经系统的发育、突触消除、神经网络的成熟等生理过程。在各种中枢神经系统损伤中,包括脑或脊髓外伤性损伤、脑或脊髓缺血再灌注损伤,补体也参与其病理进程。很多研究表明在发生神经系统损伤时,抑制补体激活具有神经保护作用,这也为预防和治疗中枢神经系统损伤提供了新的思路。
The complement system is a major component of the innate immune system. Several studies have dem- onstrated that virtually all of the components of complement can be synthesized within the CNS and a variety of comple- ment receptors were expressed on neurons, astrocytes and mieroglial cells. Complement activation participated in various aspects of both normal central nervous system （CNS） function and pathology. Various studies have revealed particularly novel findings on the wide-ranging involvement of complement in neural development, synapse elimination and maturation of neural networks. In addition, the progression of pathology in a range of brain or spinal cord injury, including ischemia- reperfusion injury or stroke, traumatic brain injury （TBI） and spinal cord injury （SCI）, where rapid disruption of neuro- nal homeostasis potently triggers complement activation. Inhibition of complement activation had been found neuroprotec- tire effects in the CNS injury. So complement-targeted therapeutics maybe a new method to alleviate the devastating con- sequences of these neurological conditions.
出处
《西部医学》
2013年第12期1906-1908,共3页
Medical Journal of West China
基金
国家自然科学基金资助项目(30973023)
关键词
补体激活
中枢神经系统
损伤
Complement activation
Central nervous system
Injury
