摘要
目的探讨可溶性 Fas(s Fas)在 Graves’病 (GD)发病过程中的作用。方法应用夹心酶联免疫吸附法(EL ISA) ,测定了 6 8例 GD患者和 2 0例健康对照者 s Fas含量。结果 1GD患者未治疗组和缓解组血清 s Fas水平高于健康对照组 ;2 GD患者未治疗组和缓解组 s Fas.TRAb乘积高于健康对照组 ;3血清 s Fas与 TRAb呈正相关关系 ,与游离 T3、游离 T4和促甲状腺素 (TSH)无相关关系。结论 s Fas参与了 GD发病与转归的病理生理过程 ,可以作为
ObjectiveTo investigate the concentration of soluble sFas(sFas) in Graves’disease(GD) and its clinical significance MethodsSerum levels of sFas in 68 cases of GD patients and 20 cases of healthy subjects were measured with a sandwiched ELISA method Results①Serum sFas levels of GD untreated group and remission group were much higher than those of healthy controls(2 08±0 82, 1 11±0 31 vs 0 70±0 5 0 ng/mL, P <0 001);② Multiplier of sFas TRAb in GD untreated group and remission group were much higher than those of healthy controls(80 01±57 62, 3 34±1 69 vs 0 81±0 80, P <0 001);③The concentration of serum sFas was significantly correlated with anti thyrotropin(TSH) receptor antibody titers(r=0 309, P <0 05),but not with other clinical parameters(free triiodothyronine,free thyroxine and TSH) (r=0 041 —0 146, P >0 05) Conclusion Serum sFas may play a pivotal role in the pathogenesis of GD
出处
《免疫学杂志》
CAS
CSCD
北大核心
2001年第1期56-57,共2页
Immunological Journal
