摘要
[目的]观察氧化苦参碱对急性胰腺炎(acute pancreastitis,AP)患者血清肿瘤坏死因子-α(TNF-α),白细胞介素-l(IL-1)和白细胞介素-6(IL-6)水平及临床疗效的影响。[方法]60例AP患者随机分为2组,对照组30例,给予止血、补液等常规处理;治疗组30例,在常规处理基础上加用氧化苦参碱治疗。观察2组治疗前、治疗第4天和治疗第7天血清TNF-α、IL-1和IL-6水平的变化。同时评价2组间白细胞恢复正常时间、血淀粉酶恢复时间、腹痛缓解时间。[结果]治疗第4天时2组TNF-α、IL-1和IL-6水平无明显差异(P>0.05),治疗第7天时,以上3项指标治疗组较对照组下降(P<0.05)。治疗组白细胞恢复正常时间、血淀粉酶恢复正常时间、腹痛缓解时间较对照组缩短1.13~2.58d。[结论]氧化苦参碱能早期抑制AP患者炎症细胞因子TNF-α、IL-1和IL-6的水平,从而控制炎症的发展,尽早减轻AP的临床症状,改善患者的预后,值得在有条件的医院进一步推广应用。
[Objective]To observe the effect of oxymatrine on serum TNF-α, II.-1 and 11.-6 in patients with acute pancreatitis（AP）and the effects in treating patients with AP. [Methods] Sixty cases of AP were randomly divided into 2 groups. Patients in control group（n= 30）were treated with hemostasis, infusion and other conventional treatment, and patients in treatment group（n= 30）were given oxymatrine addition- ally on the basis of routine treatment. Clinical efficacy was investigated in the two groups. The serum of pa- tients before the therapy,on the 4th and 7tb day of the therapy was taken to test TNF-α,IL-1 and IL-6 levels. The recovery time of leukocyte and hemodiastase as well as the relief time of bellyache were compared between the two groups . [Results] There was no significant difference in TNF-α,IL-1 and IL-6 between the experiment group and control group on the 4th day（P^0.05）, but statistically significant on the 7th day （P%0. 05）, which were decreased by 261.61ng/L, 111.81ng/L and 21.66ng/L, respectively. The re- covery time of leukocyte count and hemodiastase and the relief time of bellyache were shortened by 1.13= 2.58 days compared to the control group. [ConclusionJ Oxymatrine can decrease TNF-a, IL-1 and IL-6 lev- els of AP patients in early stage, thus can control the inflammation development, alleviate clinical symp- toms, and improve the prognosis of the patients. It is worthy of further popularization and application in qualified hospitals.
出处
《中国中西医结合消化杂志》
CAS
2013年第12期641-643,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
