摘要
[目的]筛选出效果最好的促透剂比例。[方法]试验采用两室扩散池试验装置，选取鸽子皮肤，比较1％-5％的冰片和薄荷醇对伊维菌素的透皮吸收的量效关系，计算出12h内累计的透过量和渗透系数。[结果]冰片和薄荷醇对伊维菌素的最佳促透浓度均为4％。其中．4％薄荷醇12h的累积透过量高于4％的冰片，同时4％薄荷醇单位时间内稳定透过量高于4％冰片。[结论]体外透皮模拟试验表明薄荷醇的最佳促透比例为4％。
[ Objective] To screen the best concentration for transdermal enhancers. [ Method] Pigeon＇ s skin was cut and a 2 - chamber dif- fusion cell was adopted. Then work out the accumulated permeation and percolation coefficient within 12h through comparihg the absorbed dose of ivermectin for borneo of 1% -5% with menthol. [ Result] The results showed that the best concentration for borneo and menthol are 4%. The accumulated permeation of menthol 0f4% is higher than that of borneo in 12h. The same conclusion could also draw from percolation co- efficient. [ Conclusion] So, it can be concluded from the test that the best concentration for menthol is 4%.
出处
《安徽农业科学》
CAS
2013年第27期11061-11063,共3页
Journal of Anhui Agricultural Sciences
基金
江苏省产学研前瞻性项目(BY2011114)
南京市科技发展项目(201201026)
南京市科技计划项目(2012ZD006)
关键词
冰片
薄荷醇
促透
Borneol
Menthol
Penetration
