摘要
D-氨基酸氧化酶氧化D-氨基酸生成相应的α-酮酸和氨,还原型黄素被氧化生成过氧化氢。D-氨基酸氧化酶在精神分裂症的病理、生理学研究和D-氨基酸检测等方面都发挥着关键的作用。主要就结构已解析的几个D-氨基酸氧化酶的序列同源性、结构组成、活性中心、抑制剂以及与辅酶FAD结合能力等方面进行介绍。
D-amino acid oxidase catalyzes oxidative deamination of D-amino acids yielding α-keto acid and ammonia, the reduced flavin is reoxidized to generate hydrogen peroxide by molecular oxygen. D-amino acid oxidase plays a key role in the pathophysiology of schizophrenia research and D-amino acids detecting. Based on the three-dimensional structure of analyzed D-amino acid oxidases, the property of the enzyme could be improved by rational protein design. In order to get a better understanding of D-amino acid oxidase, the sequence homology, overall structure, the active site center, inhibitor, FAD binding site and flexible parts of DAAO were introduced.
出处
《生物技术通报》
CAS
CSCD
北大核心
2013年第12期27-35,共9页
Biotechnology Bulletin
基金
河北省自然科学基金项目(C2011205045)
河北省科技支撑项目(10205521D)
河北省留学回国人员资助项目(20100705)
河北省高等学校科学技术研究青年基金项目(2011102)
河北师范大学重点基金项目(L2012Z12)
