摘要
评价阿奇霉素治疗细菌性感染的疗效与安全性。采用随机对照多中心分组研究方法 ,将 94例下呼吸道感染病人随机分为 2组 (每组 47例 )。试验组用阿奇霉素 0 .5 g加入 5 %葡萄糖注射液 5 0 0 ml静脉滴注 ,qd,5～ 7d为一个疗程 ;对照组用乳糖酸红霉素 0 .5 g加入 5 %葡萄糖注射液 5 0 0 ml静脉滴注 ,bid,5～ 7d为一个疗程。另 12例 (4例盆腔炎和 8例下呼吸道感染 )为开放组 ,以阿奇霉素治疗。结果 ,试验组痊愈率(6 1.7% )、有效率 (91.5 % )、及细菌清除率 (95 .8% )均极显著高于对照组 (31.9%、70 .2 %、76 .6 % )。以阿奇霉素治疗的 5 9例患者 ,总有效率为 93.2 % ,痊愈率 6 2 .7%。试验组不良反应率为 12 .8% ,亦显著低于对照组(34.0 % )。结论 :阿奇霉素是治疗院外获得性呼吸道与泌尿生殖道感染的有效和安全的药物。
AIM: To evaluate the efficacy and safety of azithromycin in the treatment of bacterial infections. METHODS: The 94 patients with lower respiratory tract infection were divided at random into 2 groups (47 for each group). The treatment group were treated with azithromycin 0.5g in 5% glucose injection 500ml, iv drip, qd for 5~7d. The control group were given erythromycin lactobionate 0.5g in 5% glucose injection 500ml, iv drip, bid for 5~7d. Another 12 patients (including 4 patients with pelvic inflammatory disease and 8 patients with lower respiratory tract infection) were treated with azithromycin as the open group. RESULTS: The treatment group yielded a cure rate of 61.7% and a response rate of 91.5% and a bacterial clearance rate of 95.8%, which were higher than those of the control group 31.9%, 70.2% and 76.6% ( P <0.01), respectively. The total response rate and the cure rate of 59 patients treated with azithromycin was 93.2% and 62.7%. The incidence of clinical adverse drug reactions of the treatment group was 12.8%, which was lower than that of the control group 34.0% ( P <0.05). CONCLUSION: Azithromycin is an effective agent in the treatment of the acquired lower respiratory tract infection and urogenital tract infection with slight adverse reaction.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第6期447-449,454,共4页
Chinese Journal of Antibiotics
