摘要
利用磁性纳米粒子在交变磁场作用下的磁热效应,来实现对Fe3O4/P(NIPAAm-co-Am)复合微球温度的控制,以达到肿瘤热疗与化疗联合治疗的目的。主要研究了交变磁场作用下复合微球的磁热性能的影响因素。研究结果表明,所制备的Fe3O4/P(NIPAAm-co-Am)复合微球具有很好的超顺磁性,且在交变磁场作用下具有很好的磁热效应,其磁热效应可以通过调节微球的浓度、交变磁场的磁场强度和频率等因素来调控,以适应不同应用场合需求。
Research on the magnetic thermo-sensitive composite microspheres for controlled release drug carrier was meaningful. Magnetocaloric effect was used to heat the Fe304/P （NIPAAm-co-Am） composite micro spheres, and the heat generation abilities of the composited microspheres in alternation magnetic field （AMF） were investigated in the present work. Results show the resultant Fea04/P（NIPAAm-co-Am） composite mi- crospheres exhibite excellent superparamagnetic and high heating generation ability. The temperature of the composite microspheres was raised after exposed to AMF, which can stimulate the shrinks of P（NIPAAm-co- Am）. Furthermore, the temperature raised after exposed to AMF can be adjusted by controlling the concentra tion of composite microspheres, the magnetic intensity and the freauencv of the AMF
出处
《功能材料》
EI
CAS
CSCD
北大核心
2013年第B12期273-276,共4页
Journal of Functional Materials
基金
国家自然科学基金资助项目(51102131)
关键词
肿瘤磁热疗
化疗
磁热效应
温敏性聚合物
药物控释
hyperthermia
chemotherapy
magnetocaloric effect
thermo-sensitive polymer
controlled release
