摘要
目的探讨慢性阻塞性肺疾病（COPD）急性加重期患者血浆D．二聚体（D。D）和纤维蛋白原（FIB）水平的变化及其在预后中的意义。方法将244例按病情严重程度分期、分度的COPD患者设为A组，选择同期60例健康人群作为B组，检测两组的血浆D．D和FIB含量，并分析比较各组间D。D和FIB水平的差异。结果A组患者血浆D—D和FIB含量分别为（1．11±0．49）mg／L、（5．1±1．1）g／L，均较B组明显升高（t=3．193、2．551，均P〈0．05）。COPD急性加重期患者血浆D—D和HB的含量分别为（1．49±0．79）mg/L、（5．8±1．2）g／L，明显高于COPD稳定期患者（t=2．417，1．930，均P〈0．05）。结论COPD患者存在较为明显的血液高凝状态，且随着病情的加重而加重，监测患者的血浆D．D和FIB含量对患者预后评估有重要意义。
Objective To investigate the changes of plasma D-dimer and fibrinogen levels in chronic ob- structive pulmonary disease （COPD） patients with acute exacerbation and its prognostic significance. Methods 244 COPD patients with different severity stages were selected as group A 60 healthy people at the same period were se- lected as group B The plasma levels of D-dimer and fibrinogen were detected and compared between the two groups. Results The plasma D-dimer and fibrinogen levels of group A were （ 1.11 ± O. 49） mg,/L, （5.1 ± 1.1 ） g/L, which were significantly higher than those of group B （ t = 3. 193,2. 551, all P 〈 O. 05 ）. The plasma D-dimer and fibrinogen levels in acute exacerbation of COPD were （ 1.49 ± 0.79 ） mg/L, （ 5.8 ±1.2 ） g/L, which were significantly higher than those in patients with stable COPD （ t = 2.417,1. 930, all P 〈 0.05 ）. Conclusion COPD patients have obvious hypercoagulable states, and as the disease worsens, the state aggravated. The plasma D-dimer and fibrinogen are im- portant to predict the prognosis of patients.
出处
《中国基层医药》
CAS
2013年第24期3686-3688,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肺疾病
慢性阻塞性
嘧啶二聚物
纤维蛋白原
预后
Pulmonary disease, chronic obstructive
Pyrimidine dimers
Fibrinogen
Prognosis
