摘要
目的 探讨硝苯地平作为宫缩抑制剂防治早产的临床疗效.方法 选择2011年1月～2012年12月早产临产及先兆早产孕妇122例,随机分为观察组和对照组,观察组60例采用硝苯地平治疗,对照组62例采用硫酸镁治疗,对比两组疗效及药物不良反应.结果 硝苯地平组及硫酸镁组治疗后显效时间分别为（40.12±19.48）min及（43.23±18.76）min;保胎成功率分别为78.3％ （47/60）及74.1％（46/62）,两组差异无统计学意义（P＞0.05）;新生儿分娩时体重、Apgar评分差异无统计学意义（P＞0.05）.硝苯地平组发生药物不良反应6例,硫酸镁组发生药物不良反应20例,两组差异有统计学意义（P＜0.05）.结论 硝苯地平防治早产的疗效与硫酸镁相近,但药物不良反应小,口服给药方便,母胎安全性高,值得临床推广应用.
Objective To explore the clinical effects of nifedipine as tocolysis in the prevention and treatment of pre- mature labor. Methods 122 women with preterm labor or threatened premature labor from January 2011 to December 2012 were randomly divided into observation group and control group. In the observation group （n=60）, patients were provided with nifedipine while in the control group （n=62）, patients were treated by magnesium sulfate. The therapeu- tic effects and adverse drug reactions （ADR） in both groups were compared. Results Effective time in the observation group and control group after treatment was（40.12±19.48） min and （43.23±18.76） min respectively. The success rates of prevent miscarriage were 78.3%（47/60） and 74.1%（46/62）. The above indexes didn＇t display significant differences in both groups （P〉0.05）. The birth weight and Apgar scoring showed no statistical differences in the two groups （P〉 0.05）. The number of ADR cases in the observation group and control group was 6 and 20 cases in turn, which dis- played a statistical difference （P〈0.05）. Condusiola In the prevention and treatment of premature labor, the effect of nifedipine is similar to magnesium sulfate, but with lower occurrence of ADR, more convenient oral administration, and safer to mother and fetus, which is worthy of expansion in clinic.
出处
《中国当代医药》
2013年第32期82-83,共2页
China Modern Medicine
基金
江西省新余市科技计划项目(20123090820)
关键词
硝苯地平
硫酸镁
早产
Nifedipine
Magnesium sulfate
Premature labor
