摘要
目的 :探讨 1 5 3Sm-乙二胺四甲基膦酸盐 (1 5 3 Sm - EDTMP)治疗前列腺癌伴骨转移的治疗效果。方法 :对39例前列腺癌伴骨转移的患者应用 1 5 3 Sm - EDTMP进行治疗 ,并对其止痛效果、病灶变化和毒副作用进行观察。结果 :骨痛完全缓解 12例 (30 .8% ) ,部分缓解 2 2例 (5 6 .4% ) ,总有效率为 87.2 %。 2~ 6个月 X线和骨扫描复查 ,病灶消失 4例 ,部分消失和变浅 7例 ,有效率为 2 8.1%。治疗 1周后 ,白细胞和血小板稍下降 ,停药 4周后恢复至治疗前水平。结论 :对前列腺癌伴骨转移的患者 ,尤其是有骨痛者 ,采用 1 5 3Sm- EDTMP治疗效果肯定 ,副作用小 ,安全可靠。
Purpose:To study the efficiency of 153 Sm EDTMP radiotherapy for osseous metastases in prostate cancer.Methods:36 patients with osseous metastases of prostate cancer underwent 1~3 dose treatment by 153 Sm EDTMP radiotherapy. The alleviation of pain, change of focus and toxic action were evaluated.Results: 12 patients ( 30.8 %) experienced bone pain disappearance, and 22 relieved ( 56.4 %), so total efficiency amounted to ( 87.2 %). Following up for 2~6 months after 153 Sm EDTMP radiotherapy, the X ray and bone radionuclide imaging exam showed that 4 patients achieved complete focus disappearance, and 7 patients achieved partial focus disappearance, the response rate is 28.1 %. The systemic radioactive effects on patients were mild, leukocytes and plateletes were only temporally decreased and selfrecovered after 4 weeks with 153 Sm EDTMP radiotherapy.Conclusions: 153 Sm EDTMP radiotherapy is a promising radiopharmaceutical to the osseous metastases in prostate cancer with a good response rate, less adverse effects.
出处
《临床泌尿外科杂志》
2000年第12期535-536,共2页
Journal of Clinical Urology