期刊文献+

^(153)Sm-EDTMP治疗前列腺癌伴骨转移的临床观察 被引量:1

The clinical study of^(153) Sm-EDTMP radio therapy for osseous metastases in prostate cancer
下载PDF
导出
摘要 目的 :探讨 1 5 3Sm-乙二胺四甲基膦酸盐 (1 5 3 Sm - EDTMP)治疗前列腺癌伴骨转移的治疗效果。方法 :对39例前列腺癌伴骨转移的患者应用 1 5 3 Sm - EDTMP进行治疗 ,并对其止痛效果、病灶变化和毒副作用进行观察。结果 :骨痛完全缓解 12例 (30 .8% ) ,部分缓解 2 2例 (5 6 .4% ) ,总有效率为 87.2 %。 2~ 6个月 X线和骨扫描复查 ,病灶消失 4例 ,部分消失和变浅 7例 ,有效率为 2 8.1%。治疗 1周后 ,白细胞和血小板稍下降 ,停药 4周后恢复至治疗前水平。结论 :对前列腺癌伴骨转移的患者 ,尤其是有骨痛者 ,采用 1 5 3Sm- EDTMP治疗效果肯定 ,副作用小 ,安全可靠。 Purpose:To study the efficiency of 153 Sm EDTMP radiotherapy for osseous metastases in prostate cancer.Methods:36 patients with osseous metastases of prostate cancer underwent 1~3 dose treatment by 153 Sm EDTMP radiotherapy. The alleviation of pain, change of focus and toxic action were evaluated.Results: 12 patients ( 30.8 %) experienced bone pain disappearance, and 22 relieved ( 56.4 %), so total efficiency amounted to ( 87.2 %). Following up for 2~6 months after 153 Sm EDTMP radiotherapy, the X ray and bone radionuclide imaging exam showed that 4 patients achieved complete focus disappearance, and 7 patients achieved partial focus disappearance, the response rate is 28.1 %. The systemic radioactive effects on patients were mild, leukocytes and plateletes were only temporally decreased and selfrecovered after 4 weeks with 153 Sm EDTMP radiotherapy.Conclusions: 153 Sm EDTMP radiotherapy is a promising radiopharmaceutical to the osseous metastases in prostate cancer with a good response rate, less adverse effects.
出处 《临床泌尿外科杂志》 2000年第12期535-536,共2页 Journal of Clinical Urology
关键词 前列腺肿瘤 Sm153-乙二胺四甲基膦酸盐 骨转移 Prostatic neoplasms Bone neoplasms 153 Sm EDTMP Drug therapy
  • 引文网络
  • 相关文献

参考文献2

二级参考文献6

  • 1刘琼英,国外医学放射医学核医学分册,1991年,15卷,121页 被引量:1
  • 2陈盛祖,中华肿瘤杂志 被引量:1
  • 3团体著者,中华核医学杂志,1993年,13卷,195页 被引量:1
  • 4孙燕,临床肿瘤内科手册(第2版),1992年 被引量:1
  • 5蔡露,国外医学放射医学核医学分册,1991年,15卷,241页 被引量:1
  • 6邓候富,中华核医学杂志,1992年,12卷,27页 被引量:1

共引文献91

同被引文献8

引证文献1

;
使用帮助 返回顶部