摘要
人乳头状瘤病毒是一种致瘤性DNA病毒 ,在其 90个亚型中以高危型HPV 16 ,HPV 18,HPV 33等与人类头颈部恶性肿瘤关系密切。其致癌机理是通过引起P5 3,pRB基因的突变 ,从而导致细胞转化及过度增殖。在不同部位的头颈部恶性肿瘤中HPV的检出率存在差异 ,口腔、口咽及喉部鳞状细胞癌中HPV检出率高而鼻咽癌中检出率低 ,在头颈部腺癌和淋巴瘤中HP的感染鲜见报道。
Human papillomavirus is an oncogenic DNA virus and has more than 90 subtypes. High risk types (HPV 16, 18, 33) are associated with many kinds of malignant neoplasms of head and neck. The HPV DNA can induce mutations of p53, RB genes and increase cell transformation and over proliferation. The frequences of HPV positive are different in malignant neoplasms from different head and neck sites. HPV was more often detected in squamous cell carcinoma of oral cavity, oropharynx and larynx. In nasopharyngeal carcinoma, adenocarcinoma or lymphoma, the expression of HPV was quite low. The detection of HPV in cervical metastatic lymph nodes can improve diagnosis of primary sites.
出处
《中国癌症杂志》
CAS
CSCD
2000年第6期569-571,共3页
China Oncology
