摘要
目的探讨术前给予帕瑞昔布钠对瑞芬太尼快通道麻醉行腹腔镜胆囊切除术后苏醒期的影响。方法择期行腹腔镜胆囊切除术患者64例,随机均分为两组,术前20min分别静注帕瑞昔布钠40mg(P组)或等量生理盐水2ml(C组)。术中持续泵注丙泊酚和瑞芬太尼维持麻醉。记录自主呼吸恢复时间、睫毛反射时间、睁眼时间、拔管时间;记录拔管后患者疼痛VAS评分、Ramsay镇静评分和躁动情况。结果两组患者的自主呼吸恢复时间、睫毛反射时间、睁眼时间、拔管时间差异无统计学意义。与C组比较,拔管后10、30、60 min P组疼痛VAS评分、躁动评分明显降低,Ramsay镇静评分明显升高(P<0.05)。结论帕瑞昔布钠能较好地减轻快通道麻醉清醒期的躁动和疼痛,明显改善患者的血流动力学和应激反应,不良反应少,提高患者苏醒期的安全性。
Objective To explore the effect of perecoxib sodium preemptive analgesia on the fast-track anesthesia in the recovery period. Methods Sixty-four patients underwent laparoseopic cholecystectomy operation were randomly divided into two groups, with 32 cases in each group. Patients in the experimental group （group P） received intravenous pareeoxib sodium （40 mg） pretreatment and those in the control group （group C） received equal volume of intravenous saline. The agitation occurrences in all patients were observed and compared. Results There were no significant differences in the time to recovery of spontaneous breathing, extubation, eyelash reflex or eye opening between the two groups. Compared with group C, the pain VAS scores at 10 min, 30 min and 60 min after extubation and the agitation scores during the recovery period decreased significantly （P〈0. 05）, whereas the Ramsay sedation satisfactory scores increased significantly in group P （P〈0. 05）. Conclusion Parecoxib sodium could reduce the fast-track anesthesia agitation and pain, improve hemodynamics and inhibit stress response in patients. It is also accompanied with less adverse reactions, thus improving patients~ safety in the recovery period.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2013年第11期1054-1056,共3页
Journal of Clinical Anesthesiology
关键词
帕瑞昔布钠
快通道麻醉
麻醉苏醒期
躁动
Parecoxib sodium
Fast-track anesthesia
Anesthesia recovery period
Agitation
