摘要
目的 比较自体血液回输及异体输血对病人T淋巴细胞及其亚群的影响。方法 6 0例脊柱四肢非肿瘤无免疫系统疾病病人随机分为三组 ,Ⅰ组 :自体输血组 (n =2 1) ,Ⅱ组 :异体输血组(n =2 0 ) ,Ⅲ组 :不输血组 (n =19)。三组病人于麻醉前、术后第 2d、第 7d检测外周静脉血内CD+ 3 、CD+ 4、CD+ 8及CD+ 4/CD+ 8比值。结果 三组病人术前各项指标无明显差异 (P >0 0 5 ) ;Ⅰ组和Ⅲ组术后第 2d、第 7d与术前比较及两组间比较无明显差异 (P >0 0 5 ) ;Ⅱ组病人术后第 2d与术前比较及与Ⅰ组、Ⅲ组术后第 2d比较CD+ 3 、CD+ 4、CD+ 8明显下降 (P <0 0 5 ) ,CD+ 4/CD+ 8比值无明显改变 (P >0 0 5 ) ,术后第 7d各组指标与术前比较及组间比较无明显差异 (P >0 0 5 )。结论 自体血液回输对病人T细胞免疫功能影响较小 ,异体输血则对其有抑制作用。
Objective To evaluate the effects of autotransfusion and allogenic transfusion on T lymphocyte and subsets in patients undergoing orthopedic surgery under general anesthesia Methods Sixty patients scheduled for elective orthopedic surgery without immune system disorder or tumor were randomly divided into three groups: group Ⅰ autotransfusion group (n=21), group Ⅱ allogenic transfusion group(n=20), group Ⅲ no transfusion group(n=19) Blood samples were taken from peripheral vein before anesthesia, 2 and 7 days after surgery for measurement of CD + 3,CD + 4,CD + 8 and CD + 4/CD + 8 ratio Results The values of CD + 3,CD + 4,CD + 8 and CD + 4/CD + 8 ratio were comparable among the three groups before operation (P>0 05) No significant differences were found between group Ⅰ and group Ⅲ on the 2nd and 7th day after operation CD + 3,CD + 4 and CD + 8 values decreased markedly in group Ⅱ on the 2nd day after operation as compared with those before operation and of group Ⅰ and Ⅲ (P<0 05), but there was no significant change in CD + 4/CD + 8 ratio after operation (P>0 05) On the 7th day after operation these parameters did not differ significantly from those before operation and among the three groups (P>0 05) Conclusions Autotransfusion has less effect on patient′s T lymphocyte immune function, while allogenic transfusion can obviously inhibit patient′s T lymphocyte immune function
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第12期721-723,共3页
Chinese Journal of Anesthesiology
关键词
全身麻醉
手术中
自体
血液回输
民体
T细胞
Blood transfusion ,autologous
Blood transfusion,allogenic
T lymphocytes
