摘要
目的探讨家庭无创正压通气(NPPV)治疗稳定期慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭的临床效果。方法将2009年5月—2010年5月我院治疗的50例处于稳定期的COPD合并Ⅱ型呼吸衰竭患者随机分为治疗组和对照组,各25例。治疗组患者接受常规治疗+家庭NPPV治疗,对照组患者接受常规治疗+家庭氧疗治疗。出院后随访2年,比较两组出院时、出院2年后6 min行走距离、动脉血气分析、肺功能、辅助呼吸肌评分、生活质量、2年内再次住院次数及不良反应。结果两组患者出院时6 min行走距离、用力肺活量(FVC)、1秒用力呼气末容积(FEV1)、PaCO2、PaO2、辅助呼吸肌评分及圣·乔治呼吸问卷(SGRQ)评分比较,差异均无统计学意义(P>0.05);出院2年后治疗组6 min行走距离、FVC、FEV1及PaO2高于对照组(P<0.05),PaCO2、辅助呼吸肌评分、SGRQ评分及再次住院次数低于对照组(P<0.05)。结论长期家庭NPPV治疗稳定期COPD合并Ⅱ型呼吸衰竭疗效肯定,能改善患者呼吸肌力恢复和收缩功能、纠正缺氧和高碳酸血症、延缓肺功能衰竭、提高患者生活质量。
Objective To investigate the effect of long - term family noninvasive positive pressure ventilation （NPPV） in the treatment of stable chronic obstructive pulmonary disease with type Ⅱ respiratory failure. Methods 50 stable COPD patients with type Ⅱ respiratory failure treated in our hospital from May 2009 to May 2010 were randomly divided into treatment group and control group, 25 cases in each. The treatment group received conventional therapy ＋ family NPPV, the control group received conventional therapy ＋ family oxygen therapy. Both groups were followed - up for 2 - year after discharged, the 6 min walking distance, arterial blood gas analysis, pulmonary function, accessory muscle score, quality of life and adverse reactions of two groups were compared at discharge and 2 years after discharge, re - admission times recorded. Results There was no statistically significance difference in 6 min walking distance, forced vital capacity （ FVC ） , 1 s forced expiratory volume （ FEVI ） , PaCO2, PaO2, auxiliary ventilator score and St. George＇s Respiratory Questionnaire （SGRQ） score between the two groups were compared at discharge （P 〉0.05） ; 2 years after discharge, the 6 min walking distance, FVC, FEVI and PaO2 of treatment group were higher than those of control group （ P 〈 0. 05 ）, PaCO2, auxiliary ventilator score, SGRQ scores and re - admission times were lower than those of control group （ P 〈 0. 05 ）. Conclusion Long - term family NPPV is effective in the treatmentof stable COPD with type Ⅱ respiratory failure, which can improve respiratory muscle strength recovery and contractile function, correct hypoxia and hypercapnia, delay lung failure, improve patients＇quality of life.
出处
《实用心脑肺血管病杂志》
2013年第12期8-10,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
江西省卫生厅科技计划立项课题(20093131)
关键词
肺疾病
慢性阻塞性
呼吸功能不全
家庭
无创正压通气
治疗结果
Pulmonary disease, chronic obstructive
Respiratory insufficiency
Family
Noninvasive positive pressure ventilation
Treatment outcome
