摘要
目的：观察利拉鲁肽治疗口服降糖药治疗糖尿病效果不佳患者的疗效并观察其对患者体重、收缩压等指标的影响。方法：完全随机法将76例患者随机分成利拉鲁肽组和甘精胰岛素组，在使用原有口服降糖药的基础上，首先停用或者减量除二甲双胍之外的降糖药物，利拉鲁肽组加用利拉鲁肽，起始0.6 mg·d-1，1周后增至1.2 mg·d-1，每天固定时间一次，甘精胰岛素组皮下注射甘精胰岛素，每日睡前皮下注射，起始剂量为0.1~0.2 U·kg-1·d-1，治疗12周时复查FBG、HbA1c和收缩压、腰围（WC）、臀围（HC）等指标。结果：两组患者的FBG、HbA1c、2hBG均较入院前化验指标明显下降（P〈0.05），但A组和B组比较无统计学意义（P〉0.05）；BMI、收缩压、WC、HC方面,两组比较，差异具有统计学意义（P〈0.05），B组与治疗前比较，差异不明显（P〉0.05）。结论：利拉鲁肽可以降低口服降糖药效果不佳的2型糖尿病患者的血糖，发生低血糖的几率低，且可以改善患者的β细胞功能、收缩压和体质量。
OBJECTIVE To observe the curative effect of liraglutide in type 2 diabetes mellitus treated with oral hypoglycemic drugs poor effectively,and observe its effect on the indexes of body weight, systolic blood pressure. METHODS A completely randomized method： 76 patients were randomly divided into liraglutide group（A） and insulin glargine group（B）, based on the use of the oral anti diabetic drugs, stopping or reducing anti-diabetic drugs in addition to melbine; liraglutide group given with liraglutide, initial dose： 0. 6 mg.d-1 , increased to 1.2 mg.d-1 after 1 week, given at fixed time point once a day; insulin glargine group given with subcutaneous injection of insulin glargine before bedtime, initial dose： 0. 1 -0. 2 U.kg-1·d 1 ;after 12 weeks of treatment, measured FBG, HhA1c, systolic blood pressure, waist circumference（WC）, hip circumference （HC） and other indexes. RESULTS The indexes of FBG, HbAle, 2hBG of both groups decreased significantly as compared with pre admission t esling indexes （P〈0. 05）, but there was no statistical significance between group A and group k; （P〉0. 05 ） ; the difference in systolic blood pressure, BMI, WC, HC between the two groups was statistically significant （P〈0.05） ;corn pared with before trealment in B group, there was no significant difference （P〉0.05）. CONCLUSION Liraglutide can de crease blood glucose, reduce the bad effect of oral hypoglycemic drugs in patients with type 2 diabetic patients, has a low inci dence of hypoglyeeinia, and can improve the beta cell function, systolic blood pressure and body mass.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2013年第23期1965-1968,共4页
Chinese Journal of Hospital Pharmacy
关键词
2型糖尿病
利拉鲁肽
甘精胰岛素
type 2 diabetes mellitus
liraglutide
insulin glargine
